Innovative Strategies for Improving Sperm Lifespan during Storage

Due to the remarkable success of the Research Topic 'Novel Approaches To Predict And Improve Sperm Function During Semen Storage' and the rapidly evolving subject area, we are pleased to launch Volume II for this topic.

Artificial insemination (AI) stands as a cornerstone in the realm of assisted reproductive technologies (ART), particularly in the breeding of domestic animals and in crucial conservation efforts aimed at preventing the extinction of endangered species. AI's predominance in cattle and pig breeding globally underscores its importance, driven by the need for optimized semen storage protocols that maintain sperm vitality and function. A pivotal aspect of this optimization involves developing predictive tools and novel methodologies able to assess and enhance sperm robustness against the rigors of preservation, which could substantially improve fertilization outcomes with significant economic and ecological benefits.

This Research Topic is dedicated to unearthing new methodologies that enhance our understanding and capabilities in predicting and maintaining sperm functionality during storage periods. The focus includes identifying traits of the sperm that predict how well it can endure preservation challenges, investigating genetic factors and ejaculate characteristics that influence sperm resilience, and developing procedures that mitigate oxidative stress—a common side effect of semen storage that compromises sperm quality. Additionally, this special issue emphasizes replacing conventional antimicrobials with innovative compounds like plant extracts and antimicrobial peptides to counteract bacterial contamination without contributing to antimicrobial resistance.
The scope of the contributions for this issue is broad yet focused on several key areas:
Identification of predictive markers for sperm functionality and fertilizing potential
Analysis of factors enhancing sperm cryotolerance
Research into the lifespan of sperm under various preservation conditions
Investigation of oxidative stress impacts on sperm and ameliorative strategies
Study of bacteriospermia's effects on sperm quality during storage
Exploration of alternative substances that enhance sperm preservation
By bringing together empirical and review studies, this volume aims to present cutting-edge research that provides actionable insights and solutions for semen preservation challenges, thereby fostering greater scientific understanding and practical advancements in the field of reproductive technology.

Keywords: antibiotics replacement, antioxidants, microbial contamination, novel compounds, oxidative stress, sperm freezability, sperm markers, sperm storage

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.