ORIGINAL RESEARCH
Accepted on 14 Oct 2025
Downregulation of aquaporin 3 promotes hyperosmolarity-induced apoptosis of nucleus pulposus cells through PI3K/Akt/mTOR pathway suppression
doi 10.3389/fgene.2025.1665899
- Frontiers in Medicine
- Pathology
- Research Topics
- Regulation of intervertebral disc homeostasis and the pathological or pathophysiological alterations under various harmful stimuli during aging process
Regulation of intervertebral disc homeostasis and the pathological or pathophysiological alterations under various harmful stimuli during aging process
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Articles
ORIGINAL RESEARCH
Published on 29 Jul 2025
Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential
doi 10.3389/fimmu.2025.1606905
- 1,406 views
ORIGINAL RESEARCH
Published on 18 Jul 2025
Shared diagnostic genes and potential mechanisms between intervertebral disc degeneration and diabetes mellitus revealed by integrated transcriptomic analysis and machine learning
doi 10.3389/fendo.2025.1576826
- 1,073 views
REVIEW
Published on 04 Jul 2025
Immune microenvironment in intervertebral disc degeneration: pathophysiology and therapeutic potential
doi 10.3389/fimmu.2025.1563635
- 2,430 views
- 1 citation
ORIGINAL RESEARCH
Published on 06 Jun 2025
17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway
doi 10.3389/fcell.2025.1564458
- 1,398 views
REVIEW
Published on 03 Jun 2025
Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes
doi 10.3389/fcell.2025.1586193
- 2,277 views
ORIGINAL RESEARCH
Published on 29 May 2025
Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration
doi 10.3389/fimmu.2025.1589849
- 1,897 views
ORIGINAL RESEARCH
Published on 15 May 2025
Single-cell RNA-seq uncovers lineage-specific regulatory alterations of fibroblasts and endothelial cells in ligamentum flavum hypertrophy
doi 10.3389/fimmu.2025.1569296
- 1,624 views
ORIGINAL RESEARCH
Published on 12 May 2025
Chrysin attenuates intervertebral disk degeneration via dual inhibition of matrix metalloproteinases and senescence: integrated network pharmacology, molecular docking, and experimental validation
doi 10.3389/fmed.2025.1593317
- 1,317 views
ORIGINAL RESEARCH
Published on 15 Apr 2025
Identification of aging-related biomarkers for intervertebral disc degeneration in whole blood samples based on bioinformatics and machine learning
doi 10.3389/fimmu.2025.1565945
- 2,673 views
ORIGINAL RESEARCH
Published on 29 Jan 2025
Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis
doi 10.3389/fmed.2025.1531907
- 1,275 views
- 1 citation
ORIGINAL RESEARCH
Published on 01 Nov 2024
Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits
doi 10.3389/fmed.2024.1488727
- 1,240 views
- 2 citations
Published in
Frontiers in Medicine
Pathology
Participating Journals
Frontiers in Neurology
- 2.8 impact factor
- 5.2 citescore
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