Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant activity, is a critical factor affecting various physiological systems, including reproductive health. While the adverse effects of oxidative stress on general health are well-documented, its specific impact on sperm, oocytes, and overall reproductive health is less understood. ROS, as a primary byproduct of oxidative stress, can negatively influence sperm, oocytes, embryos, and their surrounding environments, leading to potential complications in gamete development, fertilization, and embryo implantation. Antioxidants are vital in maintaining the balance between ROS production and clearance, and any disruption in this balance can result in pathological outcomes affecting pregnancy success. Despite the recognition of these issues, there remains a significant gap in understanding the molecular and cellular mechanisms that govern these physiological and pathological processes. Addressing these gaps is crucial for advancing the diagnosis and treatment of infertility, emphasizing the need for further research into the molecular underpinnings of oxidative stress in reproductive health.
This research topic aims to advance the understanding of redox regulation in reproductive health, focusing on the processes from gametogenesis to fertilization. The primary objectives include elucidating the molecular mechanisms of oxidative stress in gametes, enhancing knowledge of reproductive health in animal models, and developing innovative methods or technologies to mitigate redox damage during sperm and egg development. By addressing these aims, the research seeks to contribute to more effective infertility treatments and improved reproductive outcomes.
To gather further insights into the complex interplay of redox regulation in reproductive health, we welcome articles addressing, but not limited to, the following themes:
- Redox regulation in spermatogenesis and oocyte maturation, focusing on oxidative balance in testicular, granulosa, and germ cells.
- The role of redox processes in autophagy and apoptosis, particularly in cell maintenance and programmed cell death.
- Investigating the biological mechanisms of gamete damage induced by dietary or environmental toxins.
- The impact of natural active substances on redox regulation and their potential benefits for reproductive health.
Keywords: Sperm, Oocyte, Gametogenesis, Oxidative stress, Reproductive health
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
