Neurogenesis Regulators in Development and Disease

Neurogenesis during brain development is a finely orchestrated process governed by the progressive and specialized divisions of stem and progenitor cells. These cells, localized within distinct domains of the embryonic nervous system, undergo meticulously timed and placed divisions that dictate neurogenic outcomes, such as the quantity and distribution of neurons. This process continues into adulthood, albeit at a reduced rate, and is known as adult neurogenesis, persisting in specific brain regions throughout an individual’s life. Regulation at the molecular level is critical, influencing not only the normal brain function but also playing a role in neurodevelopmental disorders like autism and schizophrenia.

This Research Topic aims to explore the intricacies of molecular interactions during neurogenesis and their implications for brain health and disease. It seeks to understand how transcription factors, cytoplasmic regulators, cell surface receptors, and epigenetic modifiers operate and interact during the developmental stages and in the adult brain, particularly in response to injury or in neurodevelopmental disorders. Additionally, the potential of these molecules as therapeutic targets for regenerative medicine or as factors in tumor transformation, such as glioma, is of great interest.

To gather further insights into the complexity of neurogenesis, this Research Topic encompasses a broad spectrum of studies focusing on molecular regulation during development and in the adult brain. We welcome articles addressing, but not limited to, the following themes:

o     Epigenetic regulation of neurogenesis during development
o     Roles of specific molecular regulators in producing timely output of neuronal subtypes
o     Molecular markers for subtypes of stem/progenitor cells in developing and adult brain
o     Molecular mechanisms that affect adult neurogenesis following brain injury
o     Species-specific regulation of neurogenesis
o     Impaired neurogenesis in cortical malformations
o     Neurogenesis regulators in glioblastoma progression
o     Glioblastoma stem cell neurogenic potential

The Research Topic will welcome original research papers, perspectives, and reviews, focusing on the molecular regulation of developmental and/or adult neurogenesis

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Neural stem/progenitor cell, neurogenesis, brain injury, glioblastoma stem cell, brain development

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.