Molecular mechanisms of neurodegeneration

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ORIGINAL RESEARCH

Published on 20 Aug 2025

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Alexander Erofeev
Egor Vinokurov
Anastasia Bol’shakova
Ilya Bezprozvanny
Olga Vlasova

doi 10.3389/fnagi.2025.1550673

317 views

ORIGINAL RESEARCH

Accepted on 15 Aug 2025

Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA-NCAM in brain aging and Alzheimer's disease

Oghenetega Edward Imiruaye
Isis G Perez
Brian C Carson
Christian Crouzet
Jerome Garcia
Derick Han
Subhrajit Bhattacharya

doi 10.3389/fnins.2025.1649625

271 views

ORIGINAL RESEARCH

Accepted on 11 Aug 2025

Molecular Pathogenesis of Alzheimer's Disease Onset in a Mouse Model: Effects of Cannabidiol Treatment

Mary A Bishara
Phoebe P Chum
Fritz E L Miot
Ankita Hooda
RIchard E Hartman
Erik J Behringer

doi 10.3389/fnins.2025.1667585

207 views

REVIEW

Accepted on 08 Aug 2025

The Manipulator Behind "Scissors": γ-Secretase and Its Modulators in Alzheimer's Disease

Ning Gao
Fan Xing
Juan Du
Wenxue Zhao
Sijia Wang
Meinei Chen
Xiaolong Dong
Yiming Qi

doi 10.3389/fnagi.2025.1637671

466 views

ORIGINAL RESEARCH

Published on 06 Aug 2025

Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease

Hui Liu
Chenye Li
Congchen Zhai
Mei Li
Lan Ma

doi 10.3389/fnagi.2025.1566929

534 views

REVIEW

Published on 16 Jul 2025

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

Yanrong Yang
Hua Chen
Qibing Liu
Yang Niu
Chunyang Mao
Rui Wang

doi 10.3389/fnagi.2025.1623050

1,146 views

REVIEW

Published on 15 Jul 2025

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

Amy F. T. Arnsten
Isabella Perone
Min Wang
Shengtao Yang
Stacy Uchendu
Dinara Bolat
Dibyadeep Datta

doi 10.3389/fnagi.2025.1610350

1,058 views

ORIGINAL RESEARCH

Published on 30 Jun 2025

Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson’s disease pathogenesis

Cheng Cheng
Huijia Yang
Lulu Tian
Yang Ni
Congcong Jia
Weidong Le
Qingshan Wang

doi 10.3389/fnagi.2025.1612389

1,001 views

ORIGINAL RESEARCH

Published on 24 Jun 2025

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling

Jiahui Li
Yuan Xu
Gianfranco Balboni
Ying Xia

doi 10.3389/fnagi.2025.1587219

1,120 views
1 citation

ORIGINAL RESEARCH

Published on 18 Jun 2025

The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson’s disease with diabetes co-morbidity

Xiaomin Zhang
Pengyang Du
Bo Bai
Peng Feng
Xia Lian
Christian Hölscher
Yongqing Wang
Guofang Xue

doi 10.3389/fnins.2025.1596506

1,825 views

ORIGINAL RESEARCH

Published on 23 May 2025

Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis

Chenglong Zhou
Xin Feng
Huina Liu
Ting Cai
Yihong Li
Huadong Fan

doi 10.3389/fnins.2025.1593854

1,692 views

BRIEF RESEARCH REPORT

Published on 23 May 2025

APOE genetic variability in an Egyptian cohort of PD

Eman M. Khedr
Martina B. William
Aliaa A. Elhosseiny
Ali Shalash
Gharib Fawi
Mohamed H. Yousef
Shaimaa El-Jaafary
Hamin Lee
Alina Jama
23 more
Mohamed Salama

doi 10.3389/fnins.2025.1579968

1,583 views

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Frontiers in Aging Neuroscience

Alzheimer's Disease and Related Dementias

Participating Journals

Frontiers in Neuroscience
- Neurodegeneration
- 3.2 impact factor
- 6.6 citescore

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Articles

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA-NCAM in brain aging and Alzheimer's disease

Molecular Pathogenesis of Alzheimer's Disease Onset in a Mouse Model: Effects of Cannabidiol Treatment

The Manipulator Behind "Scissors": γ-Secretase and Its Modulators in Alzheimer's Disease

Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson’s disease pathogenesis

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling

The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson’s disease with diabetes co-morbidity

Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis

APOE genetic variability in an Egyptian cohort of PD

Frontiers in Aging Neuroscience

Alzheimer's Disease and Related Dementias

Participating Journals

Frontiers in Neuroscience

Neurodegeneration