Bidirectional Gut-Brain Interactions in Modulating Central Nervous System Diseases

The study of the gut-brain axis serves as a pivotal bridge between gastroenterology and neurology, revealing a complex network of communication that impacts both health and disease. This axis links the enteric nervous system (ENS) of the gut, equipped with over 100 million neurons known as the "second brain," and the central nervous system (CNS), through a myriad of neurons, hormones, and immune signals. This interaction is crucial as it not only influences gastrointestinal functions but also has profound effects on mental health and neurological conditions.

This Research Topic aims to uncover and clarify the complex mechanisms of gut-brain communication and their therapeutic relevance in treating CNS diseases. By studying the influences of gut microbiota, inflammation, intestinal permeability, and the various neuroactive molecules produced by the gut, researchers can better understand how these factors may trigger or exacerbate CNS diseases. Emerging research into dietary modifications and microbiota adjustments offers promising strategies for manipulating these interactions to alleviate symptoms of mood disorders and other CNS-related conditions, thus highlighting the therapeutic potential of targeting the gut-brain axis.

To expand our understanding in this dynamic field, we invite submissions that explore the following areas of interest:
o Mechanisms of the Microbiome-Gut-Brain Axis: Detailed studies on cellular and molecular interactions.
o Dietary Influence on Gut-Brain Communication: How nutritional changes affect CNS health.
o Gut Microbiota Shifts Linked to CNS Disorders: Exploring changes in gut microbiome and their effects on the CNS.
o Impacts of Parasitic Infections on Neurological Health: Examining host behavior and neuropathological changes.
o Psychobiotics as Therapeutic Agents for CNS: Investigating novel gut-based therapies.
o Stress-Induced Modulation of Gut-Brain Axis: Studies on psychological stress and its effects on CNS health.
o Neuroimmune Crosstalk in Gut-Brain Interactions: Research into immune responses impacting CNS function.
o Contributions from Both Animal Models and Human Studies: Encouraging both research and review papers that provide mechanistic insights and clinical translational studies.

Keywords: gut-brain axis, enteric nervous system, central nervous system, neuroinflammation, gut microbiota, CNS diseases, dietary interventions, psychobiotics, neuroimmune interactions

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.