Metabolic and Biomechanical Factors in Bone Fragility: New Frontiers in Understanding and Managing Osteoporosis

Bone fragility is influenced by a combination of metabolic dysfunction and biomechanical stress, particularly in individuals with metabolic and endocrine disorders such as diabetes, obesity, and chronic kidney disease. Recent advancements in imaging techniques and biomechanical modeling are helping to reveal how these factors impact bone health, leading to a deeper understanding of osteoporosis and other metabolic bone diseases.

This research topic aims to gather original research and review articles that explore the broader metabolic and biomechanical factors contributing to bone fragility. The goal is to enhance the clinical understanding of how metabolic dysfunction and mechanical forces interplay in bone health and to identify potential pathways for therapeutic intervention.

Topics of interest include, but are not limited to:

· The impact of metabolic disorders, such as diabetes and chronic kidney disease, on bone integrity and fragility

· Advances in biomechanical modeling to evaluate bone load, stress distribution, and fracture risk

· The relationship between systemic metabolic biomarkers and bone structural changes in endocrine-related diseases

· Opportunities for using imaging techniques to assess bone quality and strength, extending beyond traditional BMD metrics

· Cross-talk between metabolic factors and bone remodeling processes in the context of osteoporosis

· Sex- and age-related metabolic influences on bone strength and fragility

Keywords: Bone Fragility, Metabolic Dysfunction, Biomechanical Stress, Osteoporosis, Metabolic Bone Diseases, Biomechanical Modeling, Fracture Risk, Systemic Metabolic Biomarkers, Bone Remodeling, Imaging Techniques

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.