New Insights into the Pathogenesis, Diagnosis and Therapy of Chronic Heart Failure in Nonischemic Cardiomyopathies

Cardiovascular medicine continues to grapple with the complexities of chronic heart failure (CHF), a condition predominantly arising from non-ischemic cardiomyopathies (NICM). This field has seen significant advancements in the understanding of pathogenesis and therapy, yet the incidence of CHF continues to rise, underscoring an urgent need for novel diagnostic and therapeutic strategies. CHF associated with NICM presents a unique challenge due to its heterogeneous etiologies, varying from genetic mutations to systemic diseases, which complicates both diagnosis and management.

This Research Topic aims to dissect the intricate mechanisms of CHF pathogenesis in the context of NICM, establishing connections between molecular abnormalities and clinical manifestations. By solving these puzzles, the goal is to enhance diagnostic accuracy and personalize therapeutic approaches. As such, contributions are invited to explore innovative biomarkers, state-of-the-art imaging techniques, and cutting-edge treatment modalities. Research should not only focus on the refinement of existing practices but also the development of novel approaches that can significantly alter the clinical trajectory of patients suffering from this debilitating condition.

To enable a comprehensive exploration of these areas, the scope of this Research Topic includes:
• Defining genetic and molecular profiles specific to different forms of NICM.
• Evaluating the efficacy of emerging diagnostic tools in early and accurate detection of CHF.
• Investigating new pharmacological treatments and their long-term outcomes in NICM patients.
• Assessing the role of lifestyle and other non-pharmacological interventions in the management of CHF.
To gather further insights, we welcome articles addressing, but not limited to, the following themes:
• Case reports that detail unusual presentations of NICM or novel treatment approaches.
• Review articles summarizing current knowledge on the molecular underpinnings of NICM and their link to CHF.
• Clinical trials that evaluate new drugs or treatment protocols.
• Studies on the psychosocial impact of CHF on patients with NICM and their management strategies.
This topic invites researchers to share their latest findings and contribute to an evolving area of cardiovascular medicine that promises to enhance patient outcomes through tailored therapeutic strategies and improved diagnostic accuracy.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review

Keywords: Non-ischemic Cardiomyopathies, Chronic Heart Failure, Molecular Pathogenesis, Diagnostic Biomarkers, Therapeutic Innovation, Personalized Medicine

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.