The study and regeneration of dental and maxillofacial tissues are pivotal in maintaining aesthetic appearance and daily functions. Conditions including developmental abnormalities, trauma, and tumors may cause significant deformities, requiring comprehensive scientific exploration. The blending of basic sciences with preclinical investigations offers insights into enhancing diagnostic and therapeutic outcomes through layered analyses. Emerging evidence points to stem cells playing critical roles in tissue homeostasis and regeneration, with biomechanical considerations crucial in shaping diagnostic and therapeutic approaches. Furthermore, metabolism and immune responses also impact tissue regeneration, underlying the complexity of the cellular and mechanical processes involved.
The goal of this research topic is to explore the latest advances in the interdisciplinary fields of stem cells and biomechanics, in the application of dental and maxillofacial tissue development, regeneration, and related disease diagnosis and treatment. This topic seeks to explore the potential pathogenic mechanisms through basic experiments in order to identify drug targets, propose novel strategies for tissue regeneration, development, and cancer treatment by combining stem cells and novel biomaterials. This topic also seeks deeper insights into the shortcomings of current treatment techniques from clinical cases, and improvement of diagnosis and treatment techniques and devices through combination of biomechanical analysis, artificial intelligence assistance, and so forth.
In this research topic, we sincerely encourage contributions from researchers that explore themes include the following, but are not limited to:
o The functions of various stem cell lineages in dental and maxillofacial tissue development and regeneration
o Advanced stem cell therapy techniques for the regeneration of soft and hard tissues in the dental and maxillofacial regions
o Development and application of targeted pharmacological agents and novel scaffolds in tissue therapy
o Optimization technological models for in vitro expansion or modification of stem cells
o Biomechanical study and finite element analysis on the influence of dental and maxillofacial structures and device design on orthodontic arch expansion efficacy
o Innovative therapeutic strategies emphasizing regeneration, diagnosis, and disease management in dental and maxillofacial fields
Please note that article types of Case report, Data report or Hypothesis are not accepted in this topic.
Keywords: Dental and maxillofacial tissues, Stem cells, Biomechanics, Tissue engineering
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
