Exploring Extracellular Vesicles in Intervertebral Disc: Degenerative Mechanisms and Regenerative Application

Extracellular vesicles (EVs) have constituted a prominent area of research in recent years. As a mediator of intercellular communication, EVs play an undeniable role in the pathogenesis, diagnosis and treatment of intervertebral disc degenerative disease. The precise pathological mechanism by which it contributes to the progression of intervertebral disc degeneration remains unclear and requires further in-depth research. Additionally, EVs are regarded as a novel nano-sized biomaterial, with specific sources of EVs representing a potential avenue for tissue repair. The question of how EVs might be employed for intervertebral disc regeneration represents a significant area of current research interest.

The objective of this Research Topic is to enhance our comprehension of the role of EVs in the etiology, diagnosis and treatment of musculoskeletal disorders. The focus will be on elucidating the molecular mechanisms of EVs in intervertebral disc degeneration. Additionally, this topic aims to investigate the therapeutic applications of EVs and EV-based biomaterials combined with new biosynthetic technologies such as 3D printing in intervertebral disc regeneration.

We welcome articles addressing, but not limited to, the following themes:
• Biochemical and biological roles of EVs in intervertebral disc auxology and homeostasis.
• Advances in EV-based therapeutics for intervertebral disc degeneration.
• EVs isolation, identification, classification, and biogenesis mechanisms.
• Pathological mechanisms of EVs in intervertebral disc degeneration.
• Developing and designing biomaterials for EV-based therapeutic delivery in intervertebral disc regeneration.
• Synthesis and applications of EV-based materials in clinical settings.
• Application of EV combined with biological devices in sports medicine.

Contributions may focus on critical roles in EV biological or pathological roles and their therapeutic applications, with or without other biomaterials. This will guide future research in this vibrant and transformative field of biology.