Elucidating GPCR Dynamics and Signaling to Develop Innovative Therapeutic Strategies for the Prevention and Management of Age-related Diseases

G protein-coupled receptors (GPCRs) are essential for transmitting extracellular signals into cells and are implicated in the progression of age-related diseases such as neurodegenerative, cardiovascular, and metabolic disorders. Recent advancements in understanding GPCR conformational changes and biased signaling have highlighted their critical roles in disease mechanisms. Age-related alterations in GPCR function, dynamics, and expression are emerging as key factors in the pathogenesis of these conditions, making them crucial therapeutic targets.

This Research Topic aims to elucidate GPCR dynamics, focusing on age-related changes and disease progression mechanisms. By understanding the interplay between conformational changes, biased signaling, and receptor complexes, the goal is to develop innovative therapies and drugs targeting these pathways. Leveraging advanced control of biased signaling and receptor complexes, the Research Topic seeks to create novel, personalized treatment approaches for age-related diseases, contributing to their prevention and effective management while advancing therapeutic innovation.

There will be a focus on studying the behavior of the AT1 receptor, a member of the GPCR family, and its relationship with pathological conditions. The AT1 receptor has the potential to form complexes with other receptors, leading to signaling and dynamics distinct from those of the receptor alone, which may result in previously unknown pathological mechanisms. The Research Topic aims to elucidate these novel mechanisms, with a particular focus on the connection between age-related changes in receptor dynamics and age-related diseases such as hypertension, dyslipidemia, and diabetes. Additionally, the topic will investigate the impact of aging on autophagy and the functional changes of intracellular organelles, exploring their relevance to pathological conditions.

This Research Topic aims to attract high-quality contributions from researchers and experts in the field. The Editors welcome original research articles, reviews, and perspectives that advance our understanding of GPCR dynamics in developing therapeutic strategies for age related diseases.