Brugada syndrome (BrS) is a complex cardiac condition associated with sudden cardiac death, characterized by distinct electrocardiogram (ECG) patterns. This Research Topic seeks to provide a comprehensive narrative of BrS, exploring its historical foundations, current clinical insights, and future directions.
We invite submissions including original research, systematic reviews, clinical trial reports, case studies, and expert opinions. Contributions should focus on highlighting how each phase builds on the previous one, addressing critical knowledge gaps and guiding future research and clinical practice.
Past: Foundations of Diagnosis
This section will delve into the origins of Brugada syndrome, focusing on the pioneering work that identified its typical ECG pattern. It will highlight initial case studies, the development of clinical guidelines, and early risk stratification methods. Articles should provide insights into how these foundational discoveries shaped current diagnostic criteria and clinical approaches.
Present: Advanced Understanding and Current Clinical Practice
Focusing on recent research, this section will explore the epicardial substrate of BrS, its anatomical and electrophysiological characteristics, and how these relate to ECG patterns, ventricular fibrillation inducibility, and prognosis. Discussions on integrating ECG, imaging, and electroanatomical mapping to identify high-risk patients are encouraged. Additionally, the effectiveness of catheter ablation strategies in symptomatic individuals and those with arrhythmic events will be emphasized.
Future: Novel Biomarkers and Innovative Approaches
Looking ahead, this section will focus on prospective advancements such as the role of autoantibodies and novel biomarkers in BrS pathophysiology. Articles should explore emerging molecular and genetic research, introducing future diagnostic and therapeutic avenues centered on biomarker discovery. This will highlight implications for predictive medicine, early diagnosis, and individualized treatment strategies.
By consolidating research across these phases, this Research Topic aims to build a robust framework that enhances understanding of BrS and informs future clinical practices. We invite submissions in the form of original research, reviews, clinical case reports, and expert perspectives to foster a holistic understanding of BrS evolution.
Keywords: Brugada Syndrome, ECG Patterns, History, Epicardial Substrate, Catheter Ablation, Novel Biomarkers, Autoimmunity, Risk Stratification, Clinical Guidelines, Predictive Medicine
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
