Regulatory Pathways in Immune Microenvironments for Tissue Development and Repair

Developmental biology has significantly advanced our understanding of how immune microenvironments facilitate tissue morphogenesis and repair. Immune cells within these environments are crucial, providing signals that manage inflammation, tissue remodeling, and cellular differentiation. Recent advancements in biomaterial science have shown that engineered materials can influence immune responses to enhance regeneration. These materials, designed to mimic specific tissue immune environments or to deliver therapeutic signals, can effectively integrate with immune pathways to control regenerative processes. Still, the complex interactions among immune cells, regulatory pathways, and biomaterials are not fully understood. Exploring these relationships at the molecular and cellular levels is vital for leveraging biomaterials in clinical regenerative applications and represents a promising area in regenerative medicine and tissue engineering.

This Research Topic aims to uncover and clarify the regulatory pathways by which immune cells and their signaling networks promote tissue development and repair. Despite tremendous growth in regenerative medicine, efficient control of immune responses for tissue regeneration remains a substantial challenge. Investigating the interactions between immune cells and the surrounding tissue, and understanding the molecular mechanisms of these interactions, will help identify new therapeutic targets and biomaterial approaches to enhance tissue regeneration. This Research Topic seeks to connect the dots between basic research on immune-influenced tissue development and practical applications in regenerative medicine, providing novel insights into calibrated immune pathways for improved tissue repair outcomes.

To delve deeper into the complexities of immune-regulated tissue development and repair, this Research Topic invites a range of scholarly contributions. Areas of interest include but are not limited to:
• Immune cell signaling paths in tissue development and repair.
• Design and function of biomaterials in immune microenvironments.
• Integration mechanisms of biomaterials into tissue systems.
• Applications of advanced technologies like single-cell transcriptomics and organoid models in immune-biomaterial studies.
• Development and application of immuno-modulatory biomaterials in the regeneration of bone, cartilage, skin, or organs.

Through these focal areas, the Research Topic aims to foster an interdisciplinary exchange among specialists in immunology, biomaterials science, and developmental biology, propelling advancements in regenerative medicine.