Liver diseases represent a significant global health challenge, encompassing a spectrum of conditions ranging from acute and chronic hepatitis to cirrhosis, fatty liver disease, and hepatocellular carcinoma. The liver's central role in metabolism, detoxification, and immune regulation makes it particularly vulnerable to various insults, including viral infections, alcohol abuse, metabolic syndromes, and autoimmune disorders. Despite advances in diagnostics and therapeutics, liver diseases continue to contribute to substantial morbidity and mortality worldwide.
Recent years have seen rapid progress in understanding the underlying pathophysiology of liver disorders, driven by breakthroughs in molecular biology, genetics, and immunology. These insights have paved the way for novel therapeutic approaches, including targeted pharmacological interventions, regenerative medicine, and immunotherapies. This special issue aims to provide a comprehensive exploration of liver diseases, bridging the gap between basic science and clinical application, and offering a platform for researchers and clinicians to share cutting-edge findings and innovative treatment strategies.
This Research Topic aims to enhance the understanding and treatment of liver diseases to improve patient outcomes. It focuses on pathophysiological mechanisms like inflammation, fibrosis, and metabolic and immune dysregulations. The topic will cover advancements in diagnostic tools, such as biomarkers and non-invasive methods, and new therapeutic approaches, including pharmacological treatments and gene therapies. It also explores the impact of lifestyle and dietary modifications on disease progression and discusses challenges in liver disease management, with a focus on equity in healthcare and global health disparities.
Themes of interest include, but are not limited to:
• In-depth studies on the molecular and cellular mechanisms driving liver disease pathogenesis, including inflammation, fibrosis, metabolic derangements, and immune system interactions • Novel insights into the role of the microbiome, genetic predisposition, and epigenetic factors in liver disorders • Cutting-edge diagnostic advancements, such as biomarkers, imaging modalities, and non-invasive evaluation tools, with a focus on their relevance to disease pathogenesis • Therapeutic innovations targeting the underlying mechanisms of liver diseases, including pharmacological, gene-based, and cell-based approaches • Prevention and management strategies informed by understanding disease mechanisms, including lifestyle and dietary interventions.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Conceptual Analysis
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
