Advancing Reproductive Outcomes: Integrating Molecular, Metabolic, and Endocrine Insights into Oocyte Maturation

Oocyte maturation is central to fertility treatments and reproductive health, with significant implications for both natural conception and assisted reproductive technologies (ART) such as in vitro maturation (IVM) and in vitro fertilization (IVF). While substantial progress has been made, challenges remain in optimizing the conditions that lead to improved oocyte competence and reproductive outcomes.

This research topic aims to explore the diverse factors that contribute to successful oocyte maturation, with a focus on the metabolic, molecular, and endocrine processes that underpin this complex process. Insights into how the endocrine environment and hormonal signaling pathways, such as JNK in granulosa cells, impact oocyte quality and follicular function are highly relevant.

Key areas of interest include:

• Molecular and metabolic regulation of oocyte maturation

• Endocrine influences on follicular development and oocyte competence

• Biomarkers for improving oocyte selection in ART

• Comparative studies of oocyte maturation in IVM and IVF contexts

• Translational research linking basic science discoveries to clinical improvements in reproductive health