Current Insights in Sperm Motility and Male Fertility

In the realm of reproductive health, sperm motility stands out as a critical factor significantly affecting male fertility. This functionality is central not only in natural conception but also in the success of Assisted Reproductive Techniques such as Intrauterine Insemination and IVF. Recent lifestyle changes and environmental factors have been noted to deteriorate sperm quality by influencing semen quality and sperm counts. Furthermore, conditions such as type 1 and 2 diabetes, obesity, inflammation, reactive oxygen species generation and varicocele are now recognized as significant contributors to male infertility issues, thereby highlighting a complex interplay of factors that impair spermatogenesis.

This Research Topic aims to establish a consensus on the most precise and effective methods to evaluate sperm motility and to categorize sperm kinetics based on velocity and linearity. Advances in molecular and biochemical studies have shed light on the structural inducers of signaling pathways within sperm cells. However, gaps remain in our understanding of processes such as hyperactive motility under capacitation conditions, which are crucial for advancing fertility treatments and laboratory standards.

To gather further insights into these intricate dynamics, we invite comprehensive research contributions on a variety of pertinent themes:


New techniques to determine sperm motility, including three-dimensional analysis: clinical implications and future directions.
Assessing the impact of lifestyle choices on sperm kinetics and overall motility.
The role of translational medicine in improving male fertility outcomes and detailed sperm kinetics.
Investigating causes of abnormal sperm motility and their therapeutic implications, focusing on molecular pro-survival and pro-apoptotic signaling pathways, which may lead to novel infertility treatments.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Spern Motility, Male infertility, Human sperm

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.