In the realm of dermatology, inflammatory skin disorders encompass a wide array of skin related serious conditions such as systemic lupus erythematosus, scleroderma and psoriasis etc. These conditions are predominantly characterized by a dysregulated immune response and inflammation which creates major clinical challenges. These diseases demonstrate common features involving abnormal immune responses and inflammation in the targeted organs due to the improper localization of hyperactivated immune cells via ECM-integrin signalling. These aspects underscore the complexity of diagnosing and treating such diseases and point towards the need for enhanced research into their underlying mechanisms.
This Research Topic aims to provide new insights into the complex pathways that drive inflammation in autoimmune skin disorders. By focusing on the most recent research, the goal is to advance our understanding of these conditions to improve diagnostic, preventive, and therapeutic approaches. Emphasis will also be placed on systemic inflammatory storms, the roles of ECM-integrin interactions, cell adhesion and migration dynamics, and the potential for drug discovery and repurposing strategies in addressing these challenging disorders.
To gather further insights in autoimmune skin disorders and their inflammatory mechanisms, we welcome articles addressing, but not limited to, the following sub-topics:
• Autoimmune Diseases in Dermatology: pathogenesis, pathophysiology, and therapeutic/diagnostic targets
• Novel Diagnostic Methodologies and Molecular Markers of Skin Autoimmune Diseases
• Transcriptional and Epigenetic Regulators in Skin Autoimmune Diseases
• Disease Specific Focus on Dermatological Autoimmune Diseases
• Juvenile Autoimmune Disorders of the Skin
• Cellular Involvement in Skin Autoimmune Diseases
• Biomolecules involved in the Skin Autoimmune Diseases
• Emerging Therapeutic Strategies for Skin Autoimmune Diseases
• Cell-matrix interaction in Inflammation Driven Skin Autoimmune Diseases
• Systemic Inflammatory Storms in inflammatory diseases of the skin
• ECM-Integrin Interactions in Autoimmune Skin Disorders
• Virtual Drug Screening and Repurposing
By gathering cutting-edge research and fostering interdisciplinary collaboration, this Research Topic aims to provide significant insights into the clinical and preclinical studies addressing disease and current state of knowledge in this field. We expect that it will serve as a valuable resource for clinicians and researchers to develop effective strategies for the prevention and treatment of inflammation-driven autoimmune skin disorders.
Keywords: Autoimmune diseases, Skin, Inflammation, Immune System Diseases, Extracellular Matrix, immunology
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
