Deciphering Cardiovascular Cell Heterogeneity with Single Cell RNA Sequencing

In the field of cardiovascular medicine, single-cell RNA sequencing technology represents a powerful tool for uncovering the complex heterogeneity within heart and vascular cell populations. Despite significant advances, our current understanding of the unique organotypic and angiotypic distinctions among human endothelial and mural cells remains incomplete.
This gap is particularly poignant in various health and disease states where identifying specific cellular phenotypes could substantially advance diagnostic and therapeutic approaches. By utilizing sophisticated cell clustering methods such as hierarchical clustering, researchers can delineate phenotypic correlations that offer insights into cell behaviour and the dynamic nature of cardiovascular diseases.

This Research Topic aims to elucidate the potential and current application of single-cell transcriptomics within the sphere of cardiovascular medicine. It seeks to showcase technological advances that can robustly map cell heterogeneity and follow phenotype trajectories within individuals, exploring how these may change in response to diseases. Such understanding is pivotal for advancing targeted therapies and improving outcomes for cardiovascular diseases.

To gather further insights into the methodological intricacies and clinical implications, this Research Topic welcomes contributions that explore a diverse range of themes. Contributions may include original research articles, reviews, methods, systematic reviews, brief research reports, and opinion pieces focusing on, but not limited to:

• The methodological advancements in single-cell transcriptomics for cardiovascular research

• Implications of cellular heterogeneity for targeted cardiovascular therapies

• Detailed analysis of angiotypic and organotypic diversity in cardiovascular cells

• Comparative studies on cardiovascular cell heterogeneity across different species

• Investigations into how disease and aging impact cellular composition in cardiovascular systems

• The influence of gender differences on cardiovascular cell subtype variation

By deepening our understanding of cardiovascular cell diversity and the technical challenges involved in studying it at a single-cell level, this Research Topic aims to foster innovative research directions and therapies tailored to individual cellular profiles.

Keywords: Transcriptomic, Gene expression, Endothelial cell, Mural cell, Cardiomyocytes, Cell clustering, Angiotypic diversity, Organotypic diversity, Targeted therapy

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.