Advancing Cancer Therapeutics: Targeting Oncogenic Proteins for Drug Discovery

Oncogenic proteins are essential for the development and spread of tumors, making cancer a significant worldwide health concern. These proteins promote the survival, growth, and metastasis of cancer cells and are frequently the consequence of genetic abnormalities or dysregulated signaling pathways. Precision oncology has advanced significantly as a result of targeting oncogenic proteins for drug discovery. These include small-molecule inhibitors, monoclonal antibodies, and new modalities including RNA-based therapies and PROTACs (proteolysis-targeting chimeras). Notwithstanding these developments, problems including drug resistance and tumor heterogeneity still exist, calling for creative approaches to boost treatment effectiveness. Novel oncogene targets are being identified more quickly, and patient outcomes are being improved, thanks to recent advances in structural biology, computational drug design, and biomarker-driven methodologies.

This Research Topic dives into the latest breakthroughs in targeting oncogenic proteins, showcasing innovative drug discovery approaches, the challenges of drug resistance, and how these discoveries can translate into real-world cancer treatments. By exploring these advancements, we aim to highlight the potential to transform cancer care and improve patient outcomes. We aim to bring together researchers to share breakthroughs in drug discovery, understand resistance mechanisms, and improve precision medicine. By fostering collaboration, we hope to accelerate the development of more effective, targeted treatments that can enhance patient outcomes. This Research Topic also seeks to bridge the gap between research and clinical application, ensuring that promising discoveries translate into real-world therapies that can make a meaningful impact in the fight against cancer.

To gather further insights in the challenges and opportunities within this field, we welcome articles addressing, but not limited to, the following themes:

• Advances in structure-based drug design targeting oncogenic proteins

• High-throughput screening methods for identifying potential inhibitors Molecular docking and its role in precision medicine

• Strategies to overcome drug resistance in targeted cancer therapies

• The impact of genomics and proteomics in personalizing cancer treatment

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Cancer, Protein, Drug development, Drug discover, Oncogenes

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.