Sex steroid metabolism and obesity: insights from animal studies

Sex steroid metabolism plays a crucial role in understanding obesity—a condition that has reached epidemic proportions globally. Recent research underscores the complex relationship between sex hormones, such as estrogen and testosterone, and the regulation of body weight, fat distribution, and metabolic processes. Current studies indicate that these hormones significantly modulate energy balance and influence obesity's development and progression, and may plan significant roles in sexually dimorphic incidence and risk associated with metabolic disease. Despite these insights, significant gaps remain in comprehending the detailed mechanisms through which sex steroids impact metabolic dysfunction, necessitating further targeted research in this vital area.

This Research Topic aims to dissect the mechanisms through which sex hormones influence obesity by leveraging data from various animal studies. The primary objectives are to identify how sex steroids affect fat accumulation, alter energy metabolism, and contribute to metabolic disorders associated with obesity. The hypothesis driving this investigation is that specific pathways involving sex hormones can be identified as potential targets for therapeutic interventions. Researchers are encouraged to pose specific questions that probe the influence of these steroids on obesity's onset and progression, potentially leading to innovative approaches for treatment.

To gather further insights into the interplay between sex steroid metabolism and obesity, we welcome articles addressing, but not limited to, the following themes:

• Mechanisms of sex steroid action and/or conversion in adipose tissue
• The role of estrogen and testosterone in energy homeostasis
• Influences of sex hormone metabolism on appetite and weight gain
• The contribution of sex hormones to sexually dimorphic metabolic/inflammatory disease risk
• Influence of sex hormones on gut microbiota with respect to metabolic disease
• Animal model studies dissecting hormonal pathways in obesity
• The potential for hormonal interventions in obesity management

Cross-sectional epidemiological studies and meta-analyses will not be considered for this Research Topic