Molecular Perspectives on Host-Pathogen Interactions in Immune Evasion, Viral Replication, and Pathogenesis

In the field of infectious diseases, understanding host-pathogen interactions is central to unveiling the intricate molecular dynamics exhibited by pathogens. These entities have evolved to deploy highly sophisticated strategies that suppress the host's immune responses and hijack cellular machinery, establishing a foothold for pathogenesis. Despite significant advancements in molecular biology, immunology, and structural biology, significant knowledge gaps remain regarding the exact molecular interfaces during microbial entry, replication, and the overall infection. Current studies have provided insights into immune evasion tactics, pivotal viral replication strategies, and pathogenesis, but a consolidated understanding of these processes is imperative for therapeutic advancement.

This Research Topic aims to collate cutting-edge research and discussions focused on the molecular mechanisms that govern host-pathogen interactions, explicitly addressing immune evasion, viral replication, and pathogenesis. By dissecting these complex molecular interactions, this endeavor seeks to illuminate the myriad methods pathogens utilize to manipulate host pathways. Such insights are invaluable in the context of devising innovative antimicrobial and immunomodulatory strategies that potentially bolster therapeutic interventions.

To gather further insights in the molecular landscape of host-pathogen interactions, we welcome articles addressing, but not limited to, the following themes:

- Immune evasion mechanisms and strategies used by pathogens to evade innate and adaptive immunity
- Viral replication strategies, including interactions between pathogen and host factors
- Pathogenesis and disease progression, with a focus on molecular determinants of viral virulence
- Therapeutic and vaccine implications by targeting host-pathogen dynamics
- Advances in genetic and bioinformatics research influencing therapeutic responses

This Research Topic will be of interest to researchers and professionals in: Molecular biology; Virology and infectious diseases; Immunology; Structural biology and bioinformatics; and translational medicine and drug discovery.



Article Types: We welcome submissions of Original Research Articles, Review Articles, Mini Reviews, Perspectives, and Methods Papers, encouraging interdisciplinary studies utilizing molecular biology, structural biology, virology, immunology, bioinformatics, and synthetic biology approaches.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Virulence Factors, Immune Evasion Mechanisms, Viral Persistence, Viral Replication Strategies, Therapeutic Strategies, Host Susceptibility, Immune Modulation, Tunneling nanotubes

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.