GPCRs: Signal Transduction: Volume II

Given the success of Volume I of this Research Topic, and how rapid the subject area is evolving, we are pleased to announce the launch of "GPCRs: Signal Transduction: Volume II"

GPCRs are comprised of 7 membrane-spanning domains and form one of the largest and most diverse families of membrane proteins, integral to an array of important signalling processes involved in regulating bodily functions, health and disease.

These cell-surface receptors detect a variety of extracellular signals, and subsequently interact with and activate associated G Proteins to stimulate downstream intracellular responses. These interactions are essential for a whole host of human functions, providing vital information and signals to the cell about the availability of essential resources and nutrients.

In light of the inherent role GPCRs play within the cell and human body as a whole, their function and dysfunction is often naturally involved in the pathways intrinsic in many diseases, and thus are an important drug and therapeutic target.

This Research Topic aims to bring together a community of like-minded field-experts, to help stimulate discussion and the sharing of ideas to fuel the scientific direction of future GPCR research within the field of Cellular Biochemistry. We invite submissions that contribute to the improvement of our collective understanding of the role GPCRs play in human health and disease, and welcome contributions covering all aspects of signalling transduction research in relation to GPCRs.