Surgical Management of Klinefelter Syndrome: Addressing Fertility, Cancer Risks, and Perioperative Challanges

Klinefelter Syndrome, a chromosomal disorder defined by an additional X chromosome in males (47,XXY), affects about 1 in every 500 to 1,000 male births. Despite its prevalence, the condition often goes underdiagnosed and its surgical implications widely misunderstood. This Research Topic seeks to address the various surgical dimensions involved in managing Klinefelter Syndrome, including fertility preservation, cancer risk, and operative risks. The discussion extends to overarching health consequences that impact these patients, underlying gaps and opportunities for enhanced surgical approaches.

This Research Topic aims to explore the surgical treatment of ​​​​​​​Klinefelter Syndrome with specific focus on fertility and cancer. It seeks to understand the effectiveness of contemporary surgical methods like microdissection testicular sperm extraction (micro-TESE) in enhancing reproductive outcomes. Moreover, it aims to address the pressing need for refined oncological strategies tailored to the heightened risk profiles for malignancies in ​​​​​​​Klinefelter Syndrome, such as breast cancer and germ cell tumors. In exploring these issues, the goal is to provide a clearer roadmap for managing these complex cases.

To gather further insights on these critical areas, we welcome articles that detail, but are not limited to, the following themes:

- Innovations in fertility surgeries and hormonal treatments in ​​​​​​​Klinefelter Syndrome patients
- Oncological risk assessment and surgical interventions in Klinefelter Syndrome
- Perioperative risk management for ​​​​​​​Klinefelter Syndrome patients with comorbid conditions such as osteoporosis and cardiovascular diseases
- Surgical and non-surgical approaches for managing gynecomastia and other physical manifestations of ​​​​​​​Klinefelter Syndrome
- Cross-disciplinary strategies for improving overall health outcomes in ​​​​​​​Klinefelter Syndrome

We encourage contributions that explore the intersections of urology, oncology, endocrinology, and surgical practice, to aid in creating more cohesive and effective healthcare protocols for individuals diagnosed with Klinefelter Syndrome.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Curriculum, Instruction, and Pedagogy
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Curriculum, Instruction, and Pedagogy
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Klinefelter Syndrome, Surgery, Fertility Preservation, Cancer Risk, Microdissection Testicular Sperm Extraction, Operative Challenges, Oncological Surveillance, Perioperative Management, Multidisciplinary Approach

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.