Ferroptosis: Intersections, Implications, and Innovations in Programmed Cell Death, Volume II

Ferroptosis is a regulated form of cell death linking lipid metabolism, iron homeostasis disruption, and redox biology. This distinct form of cell death is constituted by a series of events characterized by lipid peroxidation and disruptions in iron metabolism, morphologically and biochemically different from apoptosis, necrosis, and autophagy.

In this cell death type, cell membrane damage occurs via reactive oxygen species (ROS) and lipoxygenases. Mitochondrial shrinkage, increased membrane density, and loss of crista are hallmarks of the morphological changes observed, as well as biochemical markers such as glutathione (GSH) depletion and decreased GPX4 activity. Iron metabolism imbalance leads to high levels of Fe2+, which trigger the Fenton reaction and increase ROS production. In turn, ROS accelerate lipid peroxidation, a process driven primarily by the oxidation of polyunsaturated fatty acids (PUFAs) via lipoxygenases, positioning lipid peroxidation as a key driver of ferroptosis.

Following the great success of Ferroptosis: Intersections, Implications, and Innovations in Programmed Cell Death" we are excited to launch this second volume, not only to better understand the mechanisms of ferroptosis but also to stimulate discussion towards new therapeutic strategies targeting ferroptosis in the treatment of diseases such as neurodegenerative diseases, metabolic disorders and cancers.

We invite submissions focused on, but not exclusively limited to, the following themes:

1. Emerging links between ferroptosis and neurodegeneration

2. Research exploring ferroptosis as a therapeutic target for various diseases, including cancer

3. Molecular processes and signaling pathways involved in ferroptosis: elaborating the intricacies of iron metabolism, lipid peroxidation, antioxidative defense, and their regulation.

4. Intersection of ferroptosis with other cell death forms: investigating the cross-talk, synergies, and diversions.

5. Identification and characterization of specific ferroptosis markers and effectors across different cell types and biological scenarios.

6. Role of ferroptosis in various pathologies: from cancer and neurodegeneration to heart, cutaneous, and kidney diseases.

7. Studies manipulating ferroptosis for therapeutic purposes

8. Advanced technologies and methodologies for studying ferroptosis at a cellular and molecular level.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Technology and Code

Keywords: ferroptosis, cell death, programmed cell death, cancer, disease, neurodegeneration, iron

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.