Precision Strategies for Atrial Fibrillation: Diagnosis, Risk, and Treatment Innovations

Atrial fibrillation (AF) is the most widespread sustained cardiac arrhythmia globally, significantly contributing to increased morbidity, mortality, and healthcare burden while negatively impacting quality of life. Despite numerous breakthroughs in comprehending and managing AF, substantial knowledge gaps persist in elucidating its various mechanisms, optimizing risk stratification, enhancing diagnostics, and developing next-generation therapies. Beyond its well-established links with stroke and heart failure, AF is increasingly associated with systemic inflammation, obesity, sleep disorders, and structural cardiac remodeling, necessitating a contemporary, multidisciplinary approach to both research and patient care.

This Research Topic aims to provide an extensive platform for original research, translational studies, clinical trials, systematic reviews, and expert perspectives on the comprehensive spectrum of AF.

To gather further insights into advancing AF management, we welcome articles addressing, but not limited to, the following themes:

o Mechanistic Insights: Investigation of molecular, genetic, electrophysiological, and structural factors contributing to AF onset, progression, and recurrence.

o Precision Risk Stratification: Development of predictive models and biomarkers for assessing high-risk patients, thromboembolic or bleeding risk, and guiding personalized treatment.

o Advances in Diagnostics: Innovations in imaging, wearable and remote monitoring technologies, artificial intelligence, and digital health tools enabling earlier and more precise AF detection.

o Emerging Therapeutic Strategies: Exploration of pharmacological advancements, ablation techniques, device-based therapy, and interdisciplinary approaches for rhythm and rate control.

o Lifestyle and Systemic Influences: Examination of the impact of lifestyle interventions, obesity, sleep apnea, metabolic syndrome, and inflammation on AF prevention and management.

o Population Health and Global Trends: Epidemiological studies investigating disparities, prevalence, and outcomes in diverse communities.


The overarching aim is to foster holistic, personalized strategies for AF management and prevention, ultimately improving patient outcomes on a global scale.

Keywords: Atrial Fibrillation, Electrophysiology, Risk Stratification, Biomarkers, Remote Monitoring, Catheter Ablation, Pharmacotherapy, Digital Health, Lifestyle Modification, Population Health

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.