Innovative Measurement Techniques in Tissue Biomechanics: From Cellular to Whole-Body Models

Tissue biomechanics is crucial in understanding human health and disease across various biological scales, from cellular mechanics to whole-body dynamics. The mechanical properties of tissues often serve as indicators of pathological conditions such as fibrosis, cancer, cardiovascular diseases, and musculoskeletal disorders. Thus, accurate and innovative measurement techniques are essential for characterizing tissue mechanics, informing diagnosis, guiding treatment plans, and aiding the development of medical devices. In recent years, advancements in medical imaging, optical methods, sensor-based devices, and in vitro mechanical testing have enriched our ability to measure tissue mechanics. Despite these advancements, challenges in achieving higher accuracy, sensitivity, and clinical relevance remain, particularly regarding the validation and standardization of methods across different spatial scales and tissue types.

This Research Topic aims to showcase cutting-edge measurement technologies and methodologies in tissue biomechanics. The goal is to explore the breadth of investigations ranging from cellular levels to comprehensive whole-body models. We seek high-quality research that presents innovative experimental methodologies and breakthroughs in imaging and sensor technologies, along with computational or hybrid strategies for quantifying biomechanical properties in both healthy and diseased states. This encompasses studies that elucidate how these techniques improve diagnostic precision, treatment efficacy, and biocompatibility in diverse biological contexts.

Our Research Topic is broad in range, encompassing cellular to whole-body models, but relatively focused on new measurement techniques and applications. We welcome articles addressing, but not limited to, the following themes:

• Imaging-based measurement of tissue mechanics
• Optical and spectroscopic techniques for biomechanical characterisation
• Sensor-based and wearable systems for biomechanical monitoring
• In vitro and ex vivo tissue testing methods
• Cellular and subcellular biomechanical measurement techniques
• Computational and multiscale modelling methods for biomechanical models
• Artificial intelligence (AI) approaches in biomechanical measurement and analysis
• Validation and standardization of measurement methods
• Clinical applications in musculoskeletal, cardiovascular, oncological, and neurological biomechanics

Authors may submit their work across various article types, including Original Research, Systematic Reviews, and Meta-Analyses.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Tissue Biomechanics, Measurement Techniques, Medical Imaging Analysis, Computational Modelling, Experimental Methods, Validation and Standardization, Cellular Mechanics, Organ-Level Mechanics, Whole-Body Biomechanics, Multiscale Analysis

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.