Exploring the link between tuberculosis and ischemic stroke: clinical perspectives and pathways

Tuberculosis (TB) is a leading cause of infectious disease worldwide, significantly impacting both morbidity and mortality rates. In recent years, the focus has expanded from its respiratory manifestations to its systemic implications, particularly concerning the risk of acute ischemic stroke (AIS). The growing body of research indicates a significant correlation between TB, specifically its pulmonary and meningeal forms, and an increased risk of ischemic stroke. This includes the heightened probability among pulmonary TB patients and the even higher risk observed in those suffering from tuberculous meningitis (TBM). As the detailed mechanisms underlying this association remain partially understood, this Research Topic seeks to bridge that gap and foster a comprehensive examination of the interplay between TB and AIS.

This Research Topic aims to centralize and synthesize current findings on the relationship between pulmonary and meningeal tuberculosis and ischemic stroke. The intent is to elucidate the physiological, immunological, and infectious mechanisms that underpin this association, thereby clarifying the pathways through which TB may contribute to vascular damage and stroke. Additionally, by evaluating existing knowledge on risk factors and identifying research gaps, this topic aspires to lay the groundwork for more effective prevention strategies and interventions. Understanding these connections more clearly is critical for enhancing patient outcomes and reducing the significant burden of stroke in TB survivors.

To gather further insights into the intricate relationship between TB and ischemic stroke, our Research Topic will concentrate on exploring potential pathophysiological pathways and risk factors. We welcome articles addressing, but not limited to, the following themes:

- Mechanisms of inflammation-driven atherosclerosis in TB patients

- Comparative risk analysis of AIS in pulmonary TB versus TBM

- Long-term vascular impacts of TB infection post-treatment

- Role of comorbid conditions such as diabetes and hypertension in TB-related stroke risk

- Immunological responses linking TB infection and cerebrovascular events