Advances in Abnormal Growth and Development: From Mechanisms to Therapeutics

Abnormal growth and development are complex processes influenced by a multitude of genetic, hormonal, and environmental factors. These abnormalities can lead to a wide spectrum of disorders, from growth retardation and precocious puberty to skeletal dysplasias and metabolic syndromes. For example, central precocious puberty (CPP) is a condition where puberty starts earlier than normal due to premature activation of the hypothalamic-pituitary-gonadal axis. In addition, individuals with haploinsufficiency of the SHOX gene display disproportionate short stature, particularly with mesomelic limb shortening and, frequently, Madelung deformity of the forearm. Over the past decade, significant advancements have been made in understanding the underlying molecular mechanisms, particularly the role of endocrine signaling pathways. However, many questions remain unanswered, and there is a pressing need to translate these findings into effective clinical therapies. This Research Topic aims to provide a comprehensive platform for researchers and clinicians to share their latest discoveries and insights into the pathophysiology and treatment of growth and developmental disorders. By exploring the intricate interplay between hormones and developmental processes, we hope to bridge the gap between basic research and clinical practice, ultimately improving patient outcomes.

This Research Topic aims to address the critical challenges in understanding and managing growth and developmental disorders by focusing on the molecular and cellular mechanisms underlying these conditions and exploring innovative therapeutic approaches. We seek to highlight recent advances in the field and identify key research directions that could lead to more effective interventions.

We invite submissions that cover a broad range of topics related to abnormal growth and development, with a particular emphasis on the endocrine aspects. Potential themes include, but are not limited to:
• The role of growth hormone, insulin-like growth factors, and other key hormones in regulating growth and development
• Molecular mechanisms of endocrine dysfunction in developmental abnormalities
• Genetic and epigenetic factors contributing to growth disorders
• Translational research on novel therapeutic targets and interventions
• Clinical studies on the diagnosis and management of growth and developmental disorders

We welcome original research articles, reviews, and opinion papers that provide valuable insights into the mechanisms and treatment of these conditions. All manuscripts should adhere to the highest standards of scientific rigor and ethical integrity.