The intersection of hematopoietic and skeletal systems represents an intricate network where hematopoietic stem cells (HSCs), immune cells, and other blood-derived entities play vital roles in skeletal development, homeostasis, and regeneration. Current findings indicate that these hematopoietic components significantly impact bone remodeling and cartilage regeneration, while aberrations in these processes can lead to pathological conditions such as osteoporosis and leukemia. However, the molecular underpinnings of these hematopoietic-skeletal interactions remain largely uncharted. Recent studies have begun to elucidate these connections, revealing the potential for novel therapeutic strategies, yet comprehensive understanding is still lacking.
This Research Topic aims to address this gap by investigating the multifaceted interactions between hematopoietic elements and the skeletal system in both physiological and pathological contexts. Key questions include the regulation of osteogenesis, chondrogenesis, and fracture healing by HSCs, platelets, and immune cells, disruptions caused by dysregulated hematopoiesis in conditions like leukemia, and the exploration of blood-bone crosstalk as a therapeutic target for skeletal disorders. By compiling innovative research that illuminates these mechanisms, tests translational strategies, and explores advanced models, the goal is to promote interdisciplinary collaboration among hematologists, bone biologists, and clinicians, ultimately accelerating therapeutic advancements.
The scope of this Research Topic is confined to the dynamic interface of hematopoietic components and skeletal tissues. It encourages Original Research, Reviews, and Methodological Advances within these themes:
• HSC and niche interactions within bone development, leukemia progression, and skeletal metastasis.
• Platelet-derived growth factors and extracellular vesicles in cartilage and bone repair.
• Regulatory roles of immune cells, such as macrophages and Tregs, in skeletal stem cell function and tissue regeneration.
• Aberrations in hematopoiesis leading to conditions like osteoporosis, osteoarthritis, or radiation-induced bone degradation.
• Translational focus on biomaterials, cell-based therapies, and niche-targeted interventions. Manuscripts must emphasize mechanistic insights or clinical implications and case reports will not be considered.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Review
Technology and Code
Keywords: Hematopoietic Stem Cells, Bone Regeneration, Osteoimmunology, Bone Marrow Microenvironment, Translational Orthopedics, Skeletal Stem Cells
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
