Immunometabolism of Tissue Resident Macrophages

About this Research Topic

Background

Macrophages play a key role in tissue development, homeostasis and aging, they exert protective responses to infections and trauma but can also contribute to chronic inflammatory pathologies and malignant progression. Nearly all tissues are populated by resident tissue resident macrophages (TRMs). Normally, TRMs maintain their population through slow self-renewal, and their role in disease is less clear than bone-marrow derived macrophages that get recruited to these tissues. Their signature is imprinted by their environment and they display fascinating variety in morphology and function that makes them unique from peripherally derived cells. Their phenotypic and functional adaptations are facilitated by dynamic metabolic reprograming and tissue-specific nutrient availability. These nutrients work in concert to mediate energy production required for motility and signaling, anabolism for secretory function and cell proliferation, breakdown of engulfed material, lipid storage and other processes. Therefore, perturbation of these metabolic functions will have effects on tissue specific immunity.

The present issue welcomes original research articles and reviews studying the causal associations between the nature, function and cell metabolism of TRMs. Ultimately, the goal is understanding the metabolism of TRM and how they differ, or are similar, to peripherally recruited cells. Our goal is to improve the current understanding of adaptive, maladaptive and ‘exhausted’ function of TRMs in healthy conditions, disease or aging through the lens of metabolic reprograming. We are interested in revealing differences in cell metabolic changes in acute and long-term responses of TRMs. These studies will provide insight into the effectiveness of pharmacologic or transgenic modulation of metabolic pathways to regulate TRM function in vivo. We welcome studies dissecting metabolic changes in TRMs linked to acute inflammation and its resolution, chronic inflammatory conditions, autoimmunity, metabolic disease and cancer. Finally, we aim to improve current understanding on the role of metabolic reprograming of TRMs in chronic inflammatory disease via formation of immune memory or trained immunity.

Topics of interest include but are not limited to:
• Regulation of adaptive, maladaptive and "exhausted" function of TRMs by metabolic reprograming
• Effectiveness of regulation of cell metabolism to modulate TRM function in vivo
• Metabolic changes in TRMs that mediate acute inflammatory responses and resolution of inflammation in specific sites
• Immunometabolic adaptations of TRMs in chronic inflammatory, autoimmune, metabolic disease, and cancer
• Does metabolic reprograming of TRMs predispose chronic inflammatory disease via formation of immunologic memory or trained immunity?

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Tissue Resident Macrophages, tissue homeostasis, metabolic reprograming, inflammation, resolution, innate immune memory, cancer

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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