AI and Big Data Integration in Orthopedic Regenerative Medicine

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 19 December 2025 | Manuscript Submission Deadline 24 April 2026

  2. This Research Topic is currently accepting articles.

Background

The field of orthopedics is undergoing a transformative shift with the integration of artificial intelligence (AI) and big data. These technologies are redefining how researchers track and interpret cutting-edge basic research, offering unprecedented insights into patient populations and treatment outcomes. As the volume of medical data continues to grow, AI algorithms have become essential for analyzing vast datasets to detect patterns and predict disease trajectories. Big data provides a holistic view of patient variations and recovery rates, enabling more precise and targeted medical interventions. Despite significant advancements, there is still a substantial need to harness these technologies to their fullest potential, particularly in the context of regenerative medicine and tissue engineering.

This Research Topic aims to explore the transformative potential of AI and big data in the realm of orthopedic regenerative medicine and tissue engineering. The primary objectives include leveraging machine learning algorithms to refine diagnostics, personalize treatment approaches, and optimize the design of biomaterials. Key aims include enhancing the development of engineered tissues like cartilage and bone by utilizing patient-specific data to improve clinical outcomes. Moreover, the research will delve into how big data can reveal novel insights into disease mechanisms, recovery pathways, and intervention strategies. By employing AI-driven models, the speed and effectiveness of biomaterial screening and cellular response predictions can be markedly improved, creating a streamlined pathway from research to clinical application.

To gather further insights in blending advanced technologies with regenerative medicine in orthopedics, we welcome articles addressing, but not limited to, the following themes:

• AI for diagnostics and personalized treatments: Predictive models for early diagnosis and optimized therapies.
• Big data analytics: Integrating large datasets to gain insights into bone and cartilage regeneration.
• AI-driven biomaterial design: Machine learning to improve biomaterial properties and predict cellular responses.
• Regenerative and tissue engineering approaches: Strategic data-driven methods for tissue repair, including biofabrication techniques.
• Translational research: Utilizing AI-powered tools in surgical procedures and post-operative care.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Data Report
  • Editorial
  • FAIR² Data
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: artificial intelligence (AI), big data analytics, orthopedic regenerative medicine, tissue engineering (cartilage & bone), personalized diagnostics an

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

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