Community Series in Revolutionizing Immunological Disease Understanding Through Single Cell Multi-Omics Technologies: Vol. II

This Research Topic is the second volume of the “Revolutionizing Immunological Disease Understanding Through Single Cell Multi-Omics Technologies” Community Series. Please see Volume I here.



Single cell technologies, encompassing genomics and proteomics, are at the forefront of revolutionizing our understanding of biological mechanisms at the cellular level, particularly in the context of immunological diseases. These technologies have enabled researchers to dissect complex cellular processes with unprecedented detail, providing crucial spatial context that was previously unattainable. Recent advancements have led to the formulation of new signaling hypotheses and opened novel pathways for therapeutic interventions. The integration of multi-omics approaches, which combine various single cell technologies, has further enhanced our ability to explore intracellular signaling and disease pathology. Despite these advancements, challenges remain in optimizing data interpretation and understanding the full scope of these technologies' impact on immunological and cancer immunological disease pathogenesis. There is a pressing need for continued exploration and refinement of these methodologies to fully harness their potential in elucidating disease mechanisms.

This Research Topic aims to explore the emerging technological advances in single cell technologies and their significant impact on understanding and interrogating immunological disease biology. The primary objectives include examining how these technologies contribute to our knowledge of immune system orchestration against cancer and infections, as well as their role in the dysregulation observed in autoimmune diseases. We seek to address specific questions related to the technological innovations and their implications for disease pathogenesis, while also identifying the challenges and potential solutions in data interpretation and material extraction.

To gather further insights in the realm of single cell technologies for immunological disease mechanisms, we welcome articles addressing, but not limited to, the following themes:

• Advances in single cell genomics, proteomics, and multi-omics techniques.

• Impact of single cell technologies on understanding immune system function and dysregulation.

• Technological innovations in epigenomic, transcriptomic, and proteomic characterization.

• Challenges in cellular material extraction and preservation of modifications.

• Software and algorithmic developments for optimizing data interpretation.

• Case studies on the application of single cell technologies in cancer and autoimmune disease research.

• Exploration of cellular homeostasis in aging through single cell analysis.



Topic Editors Zora Modrusan, Ying Zhu, Jennie Lill are employed by Genentech Inc. and are holding shares of Roche.
The other Topic Editors declare no competing interests with regard to the Research Topic subject.