Advancing immunogenetics, volume II: From germline diversity to functional and translational insights in IG and TR loci research

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 4 January 2026 | Manuscript Submission Deadline 24 April 2026

  2. This Research Topic is currently accepting articles.

Background

This topic is the second volume of https://www.frontiersin.org/research-topics/65437/advancing-immunogenetics-challenges-and-innovations-in-ig-and-tr-loci-research

Following the success of the first volume, which brought together a diverse range of contributions on the genomic characterization and biocuration of immunoglobulin (IG) and T cell receptor (TR) loci, this second edition seeks to push the boundaries of immunogenetics research into new and translationally relevant territory. Substantial progress has been made in cataloging IG/TR gene families, building reference directories, and developing analytical frameworks. Yet, critical challenges remain — particularly in bridging the gap between germline diversity, immune repertoire dynamics, and their downstream implications for T cell function and clinical outcomes.

T & B lymphocytes lie at the heart of adaptive immunity, and their functional repertoire is tightly shaped by the germline-encoded diversity of IG and TR loci. Understanding how this genomic diversity translates into clonal selection, antigen recognition, immune regulation, and disease susceptibility represents one of the most exciting and pressing frontiers of modern immunology. By situating this second volume within the T & B cell Biology sections, we aim to highlight the direct connections between immunogenetic diversity and T cell biology, offering a platform for integrative research that spans fundamental, methodological, and translational dimensions.

This Research Topic invites original research, reviews, methods, and perspectives that address, but are not limited to, the following themes:

-Germline and Comparative Immunogenetics: Advances in allele validation, expansion of curated IG/TR directories, and cross-species comparative studies that shed light on evolutionary constraints, adaptive strategies, and translational insights into human health.
-From Locus to Function: Integrative approaches that connect germline diversity to clonal dynamics, repertoire composition, and tissue-level immune function using single-cell sequencing, spatial profiling, and multi-omics strategies.
-Methods and Infrastructures: Development of computational pipelines, benchmarking frameworks, and reproducible workflows for IG/TR analysis, alongside initiatives that promote FAIR data practices, interoperability, and global data sharing to strengthen community standards.
-Artificial Intelligence and Predictive Modeling: Application of AI, machine learning, and structural modeling to predict antibody and TCR structure–function relationships, accelerate annotation pipelines, and drive rational or generative design strategies for immunotherapeutics.
-Clinical Translation: Studies linking germline variation and immune repertoire diversity to disease phenotypes, including vaccine responsiveness, susceptibility to autoimmune disorders, and the efficacy of immunotherapies, with an emphasis on mechanistic insights grounded in T cell biology.

By building on the foundations laid in Volume I, this second edition aims to foster dialogue across genomics, immunology, computational biology, and translational research. Contributions that bridge these domains will not only deepen our understanding of IG and TR loci but also illuminate how germline and repertoire diversity informs T cell responses in health and disease.

Ultimately, this Research Topic seeks to provide a comprehensive forum for advancing immunogenetics at the intersection of fundamental biology and clinical application.

The topic editors have declared no conflict of interest <

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • FAIR² Data
  • General Commentary
  • Hypothesis and Theory
  • Methods

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Immunogenetics, IG loci, TR loci, B cells, T cells, Germline diversity, Immune repertoire, Single-cell sequencing, AI modeling, Translational immunology

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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