Frontiers | Innovative microbial chassis cells transforming bio-based product synthesis

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Background

Biotechnology and biomanufacturing are witnessing a transformative shift with the rise of chassis cells. Serving as the cornerstone of modern biomanufacturing, cell factories capitalize on the remarkable metabolic and conversion potential of microorganisms, turning basic raw materials into high-value bioproducts. The exploration of non-traditional microorganisms as new chassis cells allows the expansion of cell factory sources, leveraging the unique physiological and metabolic features of these microorganisms to foster more efficient and eco-friendly biomanufacturing processes. This innovative approach heralds a new era of environmental and industrial advancements driven by biotechnology.

The development of biological tools is instrumental in the detailed study and application of chassis cells. The integration of synthetic and computational biology tools permits a precise design and control of microbial metabolic pathways, significantly enhancing the efficiency and purity of bioproducts. These advancements significantly deepen our insights into microbial genetics and metabolic mechanisms, providing a robust foundation for biotechnological innovations. The pursuit of bioproduct synthesis is the main goal of chassis cells research. Researchers can now engineer enzymes or metabolic pathways to create novel and valuable bioproducts such as drugs, enzyme preparations, and biofuels. Through systems biology and multi-omics analyses, a profound understanding of the metabolic networks and regulatory mechanisms in bioproduct-producing strains is achieved, laying the groundwork for further improving synthesis levels and expanding application horizons.

This Research Topic aims to investigate frontier research areas related to chassis cells, with a focus on converting non-traditional microorganisms into cell factories, the development of advanced biological tools, and the synthesis and expanded application of bioproducts.

To gather further insights in these emerging fields, we welcome articles addressing, but not limited to, the following themes:
- Developing non-traditional microorganisms into chassis cells
- Development of synthetic biology tools in chassis cells
- Use of computational biology tools in chassis cells
- Application of artificial intelligence (AI) in chassis cell development
- Discovery and identification of new bio-products
- Engineering enzymes or metabolic pathways for novel bioproducts
- Systems biology and multi-omics analysis of bioproduct-producing strains
- Enhancing bioproduct synthesis through metabolic engineering strategies

We encourage various types of articles, such as original research, reviews, and case studies, to enrich this evolving research landscape.

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This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

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Data Report
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General Commentary
Hypothesis and Theory
Methods
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Keywords: Chassis cell, Cell factory, Metabolic engineering, Synthetic biology, Bioproducts, Natural products

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