SA
safa al-sarraj
King's College Hospital NHS Foundation Trust
London, United Kingdom
About this Research Topic
This Research Topic is currently accepting articles, but is closing soon.
Background
Brain tumor research has undergone significant transformation with the integration of molecular pathology and genetic profiling, enabling a deeper understanding of tumor biology beyond classical histopathological features. Traditionally, brain tumor diagnosis relied primarily on microscopic examination, which, while valuable, faced limitations in predicting prognosis and selecting targeted therapies. Recent advances in molecular genetics have uncovered numerous biomarkers and genetic alterations that influence tumor behavior, prognosis, and therapeutic response, thus creating new standards for diagnostic neuropathology.
This Research Topic aims to tackle the evolving landscape of brain tumor classification by embracing molecular and genetic data alongside conventional neuropathological assessment. We seek to highlight how novel biomarkers, next-generation sequencing, and integrative molecular analyses can improve diagnostic accuracy, guide prognostication, and inform personalized therapy. By encouraging contributions that elucidate the molecular underpinnings of diverse brain tumor subtypes, we hope to bridge gaps between laboratory findings and clinical practice, fostering the translation of molecular diagnostics into routine patient care. Further, we aim to stimulate discussion on unresolved questions, such as the clinical significance of emerging genetic alterations and the challenges of implementing advanced molecular tools in resource-limited settings.
This Research Topic welcomes research related to the molecular pathology and genetics of brain tumors. Submissions may cover, but are not limited to, the following themes:
- Identification of novel genetic alterations
- Clinical application of molecular biomarkers
- Integration of molecular data into tumor classification
- Advances in sequencing technologies
- The role of epigenetics in tumor development
We also encourage discussions on ethical, logistical, and educational challenges in the adoption of molecular diagnostics within neuropathology.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
- Brief Research Report
- Clinical Trial
- Editorial
- FAIR² Data
- General Commentary
- Hypothesis and Theory
- Methods
- Mini Review
- Opinion
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
- Brief Research Report
- Clinical Trial
- Editorial
- FAIR² Data
- General Commentary
- Hypothesis and Theory
- Methods
- Mini Review
- Opinion
- Original Research
- Perspective
- Review
- Study Protocol
- Systematic Review
Keywords: molecular pathology, brain tumors, genetic profiling, biomarkers, neuropathology, personalized medicine, sequencing, tumor classification, epigenetics, diagnostic biomarker
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
