Signaling Mechanisms in Neuro-Immune Crosstalk

Neuro immune crosstalk is communication between the nervous system and the immune system. This communication is essential for maintaining balance in the body. It also helps the body respond to injury infection and stress. Signaling pathways allow neurons and immune cells to send and receive messages. These messages influence how the body reacts in health and disease.

Neurons send signals to immune cells using neurotransmitters neuropeptides and cytokines. Immune cells send messages back using cytokines chemokines and growth factors. These interactions occur in the brain spinal cord and other tissues. They help control inflammation tissue repair and immune surveillance. When neuro-immune signaling is disrupted it can cause chronic inflammation to reduce nerve cell growth and change behavior.

Understanding these mechanisms is important for treating diseases. This includes neurodegenerative disorders, autoimmune diseases, psychiatric disorders, pedantic conditions and chronic inflammation. A pediatric solid tumor originating from neural crest–derived sympathetic progenitors, provides a compelling model to study neuro-immune interactions. Dysregulated neuro-immune crosstalk in neuroblastoma not only influences tumor growth and metastasis but also affects therapeutic responsiveness, highlighting the importance of understanding these signaling mechanisms for the development of targeted immunotherapies.

Recent research has identified key signaling pathways that drive neuro immune communication. These include NF kappa B JAK STAT and MAP kinase pathways. Different cells such as microglia astrocytes and peripheral immune cells shape the signals. Each cell type has unique roles in crosstalk. Targeting these pathways may lead to new therapies.
This Research Topic aims to gather insights from molecular, cellular, and systems-level perspectives to deepen our understanding of neuro-immune signaling. Contributions that reveal mechanisms or therapeutic targets are encouraged. Experimental models and clinical studies are welcome.

Focus Areas but not limited to
• Molecular signaling pathways in neuro immune communication
• Role of neurotransmitters neuropeptides and cytokines
• Neuro-immune interactions shaping tumor behavior in neuroblastoma
• Interaction of neurons with central and peripheral immune cells
• Function of microglia and astrocytes in immune regulation
• Disruption of neuro immune signaling in disease
• Therapeutic approaches targeting neuro immune pathways
• Experimental models to study neuro immune interactions

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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Neuroimmune crosstalk, glial-immune interactions, neuroinflammation, neuron-immune signaling

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