This section showcases rigorous, in-depth research at the intersection of computational biology and RNA science, with an emphasis on methodological innovation and practical utility. We welcome contributions that develop, evaluate, or apply computational methods, software tools, and analytical frameworks across the full spectrum of RNA bioinformatics, including but not limited to:
- Databases, knowledge graphs, and web portals for RNA data discovery, integration, and visualization
- High-throughput RNA sequencing (bulk and targeted) and advanced experimental-computational workflows
- Non-coding RNAs (miRNA, lncRNA, circRNA, piRNA, and beyond): annotation, function prediction, and regulatory modeling
- RNA networks and systems-level approaches to RNA regulation, signaling, and pathway dynamics
- RNA–RNA interactions: prediction, mapping, structural modeling, and validation strategies
- RNA sequence mapping and quantification: alignment, transcriptome assembly, isoform resolution, and error modeling
Single-cell and spatial transcriptomics: algorithms for denoising, integration, lineage inference, and cell-state dynamics
We particularly encourage submissions that: - Introduce novel algorithms or statistically principled models with clear performance benchmarking
- Deliver robust, user-friendly software, reproducible pipelines, and FAIR-compliant resources
- Integrate multi-omics data or structural information to deepen mechanistic insight
- Address scalability, interpretability, uncertainty quantification, and reproducibility in RNA analyses
- Translate methods to impactful applications in health, biotechnology, and environmental sciences
Positioned at the forefront of RNA research, this multidisciplinary section serves as a hub for disseminating cutting-edge discoveries to researchers, industry stakeholders, policymakers, and the public. By advancing the methods and tools that power modern RNA biology, we aim to accelerate understanding of RNA function, regulation, and therapeutic potential in a rapidly evolving field.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
