Applications of Human Organoids: From Disease Modeling to Drug Development

Theme Overview

This special issue will explore the diverse applications of human organoid technology across research, clinical, and translational domains. With particular emphasis on emerging applications in patient-specific drug treatment, microbiome-host interactions, and immune recognition, this collection aims to showcase how organoid systems are revolutionizing disease modeling, drug development, personalized medicine, and fundamental biological research.



Opportunities

While organoid technology has been started using significantly, many applications remain underexplored or are just emerging.

Key opportunities include:

• Drug Screening: Standardizing organoid-based drug screening and toxicity testing protocols

• Personalized Medicine: Expanding immunopeptidome within organoid models for immune recognition studies

• Microfluidic Platforms: For organoid-immune cell co-cultures and organ-on-chip applications

• Disease Modeling using molecular biology techniques: Protocol to study organoids including CRISPR/Cas9 gene editing, base/prime editing, lentiviral transduction, optogenetics, and multi-omics profiling (transcriptomics, proteomics, metabolomics)



Target Researchers

This special issue will appeal to a broad interdisciplinary researchers including organoid biologists and stem cell researchers, immunologists and cancer researchers, pharmaceutical scientists and drug developers, clinical researchers in oncology and infectious diseases, proteomics and mass spectrometry scientists, systems biologists and computational researchers, regenerative medicine specialists, bioengineers developing advanced culture systems, and translational researchers bridging basic science and clinical applications.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Human organoids Disease modeling Personalized medicine Drug screening and toxicity testing Immunopeptidomics and immune recognition Microfluidic organ-on-chip co-cultures

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.