Genetic and proteomic biomarkers in solid tumor detection and treatment

Cancer is the leading cause of death and remains a great challenge worldwide. The stage at initial diagnosis and the choice of suitable therapy can greatly affect the outcome of cancer patients. Biomarkers can help to identify cancer patients at an earlier stage and guide personalized therapy. Advances in the genomics, transcriptomics, proteomics and metabolomics have significantly improved our understanding of cancer biology. These novel understanding has brought about the evolutionary transformation in personalized cancer therapy and the prognosis of cancer has greatly improved. Molecular biomarkers have played a unique role in cancer management and treatment nowadays.

This Research Topic covers a wide spectrum of studies of genetic and proteomic biomarkers that contribute to the research filed of diagnosis and treatment in solid tumor. Research from laboratories, results from clinical trials or reports of interesting cases are within the scope of current Research Topic. Pure in silico studies without experimental validation will not be considered for this collection.

Potential subtopics are included, but are not limited to:

1. Identification, characterization and validation of genetic and proteomic biomarkers that are associated with solid tumor susceptibility, diagnosis, and therapeutics.

2. Novel techniques for identifying or capturing genetic or proteomic biomarkers in solid tumor.

3. Translational research bridging the gap between our incremental knowledge on the association of solid tumor biomarkers and characteristics, outcome of cancer patient in clinical practice.

4. Case reports of rare cancer types or interesting cases in solid tumor associated with genetic or proteomic biomarkers in clinical practice.