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Current Trends and Future Perspectives about Liquid Biopsy

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Editorial14 December 2023

Editorial: Current trends and future perspectives about liquid biopsy

Elisa Frullantiand María José Serrano

Despite rapid advancements in cancer screening and therapies, many cancer patients still succumb to 14 the disease. The molecular characteristics of tumors are commonly assessed using surgical specimens 15 or biopsy samples. However, biopsies only sample a portion of the tumor and might not fully represent 16 its heterogeneity, providing incomplete information about the genetic variability of a patient's cancer. 17Additionally, it's impractical for patients to undergo multiple biopsies of primary and metastatic lesions 18 as the tumor progresses.

2,336 views

2 citations

REVIEW

3 April 2023

Enhancing clinical potential of liquid biopsy through a multi-omic approach: A systematic review

Gianna Di Sario, 5 more and Claudia Felici

14,563 views

85 citations

REVIEW

4 August 2022

Potential utility of miRNAs for liquid biopsy in breast cancer

Xiangrong Liu, 10 more and Jinfeng Ma

8,618 views

35 citations

ORIGINAL RESEARCH

25 October 2022

Diagnostic accuracy of circulating free DNA testing for the detection of KRAS mutations in non-small cell lung cancer: A systematic review and meta-analysis

Maria Palmieri, 3 more and Elisa Frullanti

3,103 views

11 citations

ORIGINAL RESEARCH

20 April 2023

Application of circulating tumour DNA in terms of prognosis prediction in Chinese follicular lymphoma patients

Mengjing Zhao, 11 more and Liping Su

3,398 views

7 citations

ERRATUM

2 June 2023

Erratum: Application of circulating tumour DNA in terms of prognosis prediction in chinese follicular lymphoma patients

Frontiers Production Office

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Notwithstanding the fast-paced innovation in cancer screening and therapeutics, most cancer patients ultimately die because of their disease. The molecular profile of tumor is routinely evaluated by surgical or bioptic samples, however, tumor biopsies accomplish the sampling of only a part of the tumor and may only capture a fraction of its heterogeneity, consequently not being totally informative about the levels of genetic variability of a patient’s cancer. Moreover, it is unlikely for a patient to undergo sequential biopsies of primary and metastatic lesions along tumor progression.

During the last years, to answer the need of a more accessible approach for tumor genetic analysis, liquid biopsy has emerged as an innovative, non-invasive and efficient opportunity of detecting and monitoring cancer in several body fluids instead of tumor tissue. Furthermore, thanks to this approach, we are able to take more blood samples over time, informing about the type of molecular changes going on in a tumor. Circulating tumor DNA (ctDNA), Circulating tumor cells (CTCs), RNA (mRNA and microRNA), microvesicles, including exosomes and tumor educated platelets represent a source of genomic information in cancer patients reflecting all subclones present in primary and metastatic lesions allowing sequential monitoring of disease evolution.

This Research Topic aims to update the currently available information concerning liquid biopsy, the key features and their applications in oncology highlighting the technological challenges and the hurdles we need to overcome to finally see the next era of cancer care.

This Research Topic will update about the key features of liquid biopsy and their applications in oncology. In particular, we especially welcome original research articles, reviews (either systematic or discursive), and short communications of significant preliminary results that highlight the role of Liquid Biopsy in the research of novel prognostic and predictive biomarkers for cancer as well as in the monitoring of the course of the disease.

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