Drug Design And Development | List of Frontiers open access articles

Original Research

Accepted on 02 Oct 2025

Monocyte Migration Assay Using a Vascular-on-a-Chip Model and its Utilization for the Evaluation of a Heated Tobacco Product

in In Vitro Toxicology

Ayaka Hayashida
Atsuko Nozawa
Shigeaki Ito

Frontiers in Toxicology

doi 10.3389/ftox.2025.1658093

Original Research

Accepted on 02 Oct 2025

Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database

in Cancer Immunity and Immunotherapy

Yi Tang
Yongchuan She
Danping Chen
Yibo Zhou
Zhai Liu
Zhi Chen
Jun Wan
Yu Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658535

Case Report

Accepted on 02 Oct 2025

Endovascular Management of Splenic Artery Aneurysms in Women of Childbearing Age: A Case Report and a Review of Literature

in Vascular Surgery

Karim Kanbar
Nadim Muallem
Jamal Hoballah

Frontiers in Surgery

doi 10.3389/fsurg.2025.1672059

Original Research

Accepted on 02 Oct 2025

Genotypic Variation in Yield, Physiological Traits, and Drought Tolerance of Quinoa (Chenopodium quinoa Willd.) under Arid Conditions

in Plant Abiotic Stress

Magdi A. A. Mousa
Khalid A. Asiry
Adel D Alqurashi
Najeeb M Almasoudi
Mohammed I Elsayed

Frontiers in Plant Science

doi 10.3389/fpls.2025.1679444

Original Research

Accepted on 02 Oct 2025

Study on the predictive role of bile acid and lymphocyte count in the prognosis of patients with traumatic brain injury:a retrospective analysis

in Neurological Biomarkers

Jie Xu
Yinghua Song
Xiancheng Chen
Ming Chen
Yun Zhao
Zhi Li
Songyang Li
Liang Zhang
Wenkui Yu

Frontiers in Neurology

doi 10.3389/fneur.2025.1601987

Original Research

Accepted on 02 Oct 2025

Adverse childhood experiences and chronic pain in adults aged 86: findings from the Lothian Birth Cohort 1936

in Healthy Longevity

Dhaneesha Senaratne
Sam Singleton
Kate Timmins
Jeanette Spiteri
Paul Redmond
Adele Taylor
Janie Corley
Danielle Page
Janine Rennie
Huan Wang

Frontiers in Aging

doi 10.3389/fragi.2025.1657525

Original Research

Accepted on 02 Oct 2025

Supporting Sustainable Urban Transformation: A Feasibility Framework for Smart City Projects

in Innovation and Governance

Rafael Esteban-Narro
Vanesa G Lo-Iacono-Ferreira
Juan Ignacio Torregrosa-López

Frontiers in Sustainable Cities

doi 10.3389/frsc.2025.1675890

Original Research

Accepted on 02 Oct 2025

Engineering HER2-targeted biparatopic antibodies to promote receptor internalization and restore antitumor efficacy

in Cancer Immunity and Immunotherapy

Xinlin Liu
Wanpeng Yu
Yihuan Wang
Dongming Xing
Haiming Huang
Wenjing Zhu
Peng Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711433

Original Research

Accepted on 02 Oct 2025

Transcriptomics and network pharmacology reveal the potential mechanism related to integrated stress response in the treatment of osteoporosis by Jiawei Shentong Zhuyu Decoction and verified by RT-qPCR

in Bone Research

Jie Zhao
TingTing Zhang
Pengbo Han
Zhu Liu
Hongli Zhang
Fangqin Li
Gang Han

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1618296

Original Research

Accepted on 02 Oct 2025

Factors influencing the outcomes of contrast-enhanced ultrasound in the detection of sentinel lymph nodes in breast cancer

in Cancer Imaging and Image-directed Interventions

Jun Luo
Yunhao Luo
Wenbin Cao
Liting Feng
Chaonan Li
Yuyan Liu
Dayan Huang
Cheng Guan
Qiang Lu

Frontiers in Oncology

doi 10.3389/fonc.2025.1662625

Original Research

Accepted on 02 Oct 2025

Enabling Urban Climate Resilience Through Integrated Optimization of Urban Design

in Innovation and Governance

Wenhan Feng
Liang Emlyn Yang
Fan Zeng
Jing Jia
Hengrui Zhang
Zheng Wu

Frontiers in Sustainable Cities

doi 10.3389/frsc.2025.1657008

Correction

Accepted on 02 Oct 2025

Correction: Research progress on the causes and countermeasures of postoperative swelling in gluteal muscle contracture

in Geriatric Medicine

Yuxiang Ren
Li Yang
Yingyi Fan
Bixia Chen
Yanrong Tan
Sha Hu
Jiuqun Li
Cong Yang

Frontiers in Medicine

doi 10.3389/fmed.2025.1716270

Correction

Accepted on 02 Oct 2025

Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies

in Brain Health and Clinical Neuroscience

Leela Shah
Christy D. Yoon
Alessandra LaJeunesse
Lilly G. Schirmer
Emma W. Rapallini
Elizabeth M. Planalp
Douglas Dean

Frontiers in Human Neuroscience

doi 10.3389/fnhum.2025.1717377

Original Research

Accepted on 02 Oct 2025

Integrated Liquid Biopsy Model for Predicting Metastasis and Guiding PD-1 Therapy in Esophageal Squamous Cell Carcinoma

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Hailong Pang
Shenshen Hao
Shuiwang Hu
Xiaojuan Zhou

Frontiers in Oncology

doi 10.3389/fonc.2025.1673946

Original Research

Accepted on 02 Oct 2025

Revealing the Hidden Impact of SGLT2 Inhibitors on Uric Acid Levels: A Retrospective Multicenter Cohort Study

in Cardiovascular Endocrinology

Ehsan A Habeeb
Abdullah M Ghaith
Abdulmajeed Alshehri
Ghalia Aquil
Arwa H Afana
Ali H Alqarafi
Abdullah A Alahmed
, Omar S Alkhezi

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1667438

Conceptual Analysis

Accepted on 02 Oct 2025

An Integrative Cognitive Model for Multisensory Design: Benefits and Risks of AI-Personalization

in Human-Media Interaction

Roxane L. Bartoletti
Xavier Corveleyn

Frontiers in Computer Science

doi 10.3389/fcomp.2025.1652537

Articles

Monocyte Migration Assay Using a Vascular-on-a-Chip Model and its Utilization for the Evaluation of a Heated Tobacco Product

Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database

Endovascular Management of Splenic Artery Aneurysms in Women of Childbearing Age: A Case Report and a Review of Literature

Genotypic Variation in Yield, Physiological Traits, and Drought Tolerance of Quinoa (Chenopodium quinoa Willd.) under Arid Conditions

Study on the predictive role of bile acid and lymphocyte count in the prognosis of patients with traumatic brain injury:a retrospective analysis

Adverse childhood experiences and chronic pain in adults aged 86: findings from the Lothian Birth Cohort 1936

Supporting Sustainable Urban Transformation: A Feasibility Framework for Smart City Projects

Engineering HER2-targeted biparatopic antibodies to promote receptor internalization and restore antitumor efficacy

Transcriptomics and network pharmacology reveal the potential mechanism related to integrated stress response in the treatment of osteoporosis by Jiawei Shentong Zhuyu Decoction and verified by RT-qPCR

Factors influencing the outcomes of contrast-enhanced ultrasound in the detection of sentinel lymph nodes in breast cancer

Enabling Urban Climate Resilience Through Integrated Optimization of Urban Design

Correction: Research progress on the causes and countermeasures of postoperative swelling in gluteal muscle contracture

Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies

Integrated Liquid Biopsy Model for Predicting Metastasis and Guiding PD-1 Therapy in Esophageal Squamous Cell Carcinoma

Revealing the Hidden Impact of SGLT2 Inhibitors on Uric Acid Levels: A Retrospective Multicenter Cohort Study

An Integrative Cognitive Model for Multisensory Design: Benefits and Risks of AI-Personalization