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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2018.00778

Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders

  • 1Avenida Zañartu 1482. Ñuñoa. Santiago. Chile. Tel.+562 2367 2085, Fundación Ciencia and Vida, Chile
  • 2Institute in Dentistry Sciences, Dentistry Faculty. Sergio Livingstone Pohlhammer 943. Independencia. Santiago. 8380-492, Chile . Tel. +562 2978 1770, Universidad de Chile, Chile

Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major proteins players of CMA are LAMP-2A and Hsc70. Whereas LAMP-2A works as receptor for protein substrates at the lysosomal membrane, Hsc70 specifically binds protein targets and takes them for CMA degradation. Because of the broad spectrum of proteins able to be degraded by CMA, this pathway has been involved in physiological and pathological processes like lipid and carbohydrate metabolism, and neurodegenerative diseases, respectively. Both, CMA, and the mentioned processes, are affected by aging and by inadequate nutritional habits like high fat diet or high carbohydrate diet. Little is known regarding to CMA being considered as a common regulation factor that links metabolism with neurodegenerative disorders. This review summarizes what is known about CMA, focusing the attention in its molecular mechanism, its role in protein, lipid and carbohydrate metabolism. In addition, the review will discuss how CMA could be a link to connect protein, lipids and carbohydrate metabolism with neurodegenerative diseases. Furthermore, it will be discussed how aging and inadequate nutritional habits, can have an impact at both, CMA activity and neurodegenerative disorders.

Keywords: CMA, neurodegeneration, Lipids, Carbohydrates, Metabolism

Received: 19 Sep 2018; Accepted: 11 Dec 2018.

Edited by:

Maria I. Vaccaro, Universidad de Buenos Aires, Argentina

Reviewed by:

Carsten Merkwirth, Ferring Research Institute, Inc., United States
Angelo Poletti, University of Milan, Italy  

Copyright: © 2018 Alfaro, Albornoz, Molina-Berríos, Moreno, Cordero, Criollo and Budini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Ivan Alfaro, Fundación Ciencia and Vida, Avenida Zañartu 1482. Ñuñoa. Santiago. Chile. Tel.+562 2367 2085, Santiago, Santiago Metropolitan Region (RM), Chile, ialfaro@cienciavida.org
Dr. Mauricio Budini, Universidad de Chile, Institute in Dentistry Sciences, Dentistry Faculty. Sergio Livingstone Pohlhammer 943. Independencia. Santiago. 8380-492, Chile . Tel. +562 2978 1770, Santiago, 3580000, Santiago Metropolitan Region (RM), Chile, mbudini@u.uchile.cl