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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00788

Metabolic syndrome and Skin diseases

 YU HU1, 2, Yun Zhu2, Ni Lian1, Min Chen1,  Andrzej Bartke2 and  Rong Yuan2*
  • 1Institute of Dermatology, Chinese Academy of Medical Sciences, China
  • 2Southern Illinois University School of Medicine, United States

The increasing prevalence Metabolic syndrome (MetS) is a worldwide health problem, and the association between MetS and skin diseases has recently attracted growing attention. In this review, we summarize the associations between MetS and skin diseases, such as psoriasis, acne vulgaris, hidradenitis suppurativa, androgenetic alopecia, acanthosis nigricans, and atopic dermatitis. To discuss the potential common mechanisms underlying MetS and skin diseases, we focus on insulin signaling and insulin resistance, as well as chronic inflammation including adipokines and proinflammatory cytokines related to molecular mechanisms. A better understanding of the relationship between MetS and skin diseases contributes to early diagnosis and prevention, as well as providing clues for developing novel therapeutic strategies.

Keywords: metabolic syndrome, Skin Diseases, Insulin Resistance, Adipokine, Proinflammatory cytokine

Received: 29 Aug 2019; Accepted: 29 Oct 2019.

Copyright: © 2019 HU, Zhu, Lian, Chen, Bartke and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Rong Yuan, Southern Illinois University School of Medicine, Springfield, 62702, Illinois, United States, ryuan@siumed.edu