It is my great pleasure to introduce this Research Topic entitled “Targeting Different Programmed Cell Death Processes as Therapeutic Modalities for Thyroid Cancer” that specifically highlights some of the ways to target programmed cell deaths for thyroid cancer therapy. The studies in this topic also introduce some genetic and epigenetic markers for thyroid cancer prognosis and prediction.
Ferroptosis, as a novel form of programmed cell death (PCD), has been shown to have association with thyroid cancer (1). Ren et al. conducted a study that included 497 thyroid cancer RNA expression datasets derived from the cancer genome atlas (TCGA) cohort and constructed a prognostic risk model for eight ferroptosis-related genes using Lasso-Cox regression. Indeed, they aimed to evaluate relationship between these genes and prognosis and immune cell infiltration.
Immune checkpoint inhibitors are monoclonal antibodies with anticancer ability to increase overall survival in cancer patients (2). The important contribution of tyrosine kinase inhibitors (TKIs) in the treatment of TC is highlighted in a comprehensive review by Chera et al., in which immune-related adverse events (irAEs) during the thyroid cancer therapy with TKIs have been discussed. Then, the ways to manage these adverse effects have been described.
According to the literature, X-linked inhibitor of apoptosis (XIAP) overexpression and BRAFV600E mutation are associated with an aggressive phenotype of papillary thyroid carcinoma (PTC) (3, 4). Parvathareddy et al. conducted an investigation on 1600 PTC tumors to assess the prevalence of XIAP expression in combination with the BRAFV600E mutation in these Middle Eastern patients and weight their prognostic value to predict disease-free survival.
Pesticide exposure is shown as one of the important factors that may induce epigenetic alterations in different neoplastic transformations (5). Salimi et al. focus on the effect of organochlorine pesticides (OCPs) on promoter methylation of three tumor-suppressor genes and four histone modifications in thyroid nodules from 61 PTC and 70 benign thyroid nodules (BTN) patients.
I have enjoyed hosting this exciting Research Topic and I thank all the authors for their excellent contributions.
Statements
Author contributions
The author confirms being the sole contributor of this work and has approved it for publication.
Acknowledgments
I would like to thank the vice chancellor of Shahi Beheshti University of Medical Sciences.
Conflict of interest
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
Ge M Niu J Hu P Tong A Dai Y Xu F et al . A ferroptosis-related signature robustly predicts clinical outcomes and associates with immune microenvironment for thyroid cancer. Front Med (2021) 8:637743. doi: 10.3389/fmed.2021.637743
2
Shiravand Y Khodadadi F Kashani SMA Hosseini-Fard SR Hosseini S Sadeghirad H et al . Immune checkpoint inhibitors in cancer therapy. Curr Oncol (2022) 29:3044–60. doi: 10.3390/curroncol29050247
3
Gan X Shen F Deng X Feng J Lu J Cai W et al . Prognostic implications of the BRAF-V600(E) mutation in papillary thyroid carcinoma based on a new cut-off age stratification. Oncol Lett (2020) 19:631–40. doi: 10.3892/ol.2019.11132
4
Devi GR Finetti P Morse MA Lee S de Nonneville A Van Laere S et al . Expression of X-linked inhibitor of apoptosis protein (XIAP) in breast cancer is associated with shorter survival and resistance to chemotherapy. Cancers (2021) 13:2807. doi: 10.3390/cancers13112807
5
Giambò F Leone GM Gattuso G Rizzo R Cosentino A Ciná D et al . Genetic and epigenetic alterations induced by pesticide exposure: integrated analysis of gene expression, microRNA expression, and DNA methylation datasets. Int J Environ Res Public Health (2021) 18:8697. doi: 10.3390/ijerph18168697
Summary
Keywords
thyroid cancer, targeted therapy, programmed cell death, treatment, prognosis
Citation
Rajabi S (2023) Editorial: Targeting different programmed cell death processes as therapeutic modalities for thyroid cancer. Front. Endocrinol. 14:1255259. doi: 10.3389/fendo.2023.1255259
Received
08 July 2023
Accepted
13 July 2023
Published
27 July 2023
Volume
14 - 2023
Edited and reviewed by
Antonino Belfiore, University of Catania, Italy
Updates
Copyright
© 2023 Rajabi.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Sadegh Rajabi, sadegh.rajabi2017@gmail.com
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.