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Front. Immunol. | doi: 10.3389/fimmu.2018.00853


Ahmed Outlioua1, Marie Pourcelot2 and  Damien Arnoult1*
  • 1INSERM UMR1197 Unité mixte de recherche Interactions cellules souches-niches, France
  • 2INRA UMR1161 Virologie, France

After a viral infection and the stimulation of some pattern-recognition receptors (PRRs) as the TLR3 in the endosomes or the RIG-I-like Receptors (RLRs) in the cytosol, activation of the IKK- related kinase TBK1 leads to the production of type I Interferons (IFNs) after phosphorylation of the transcription factors IRF3 and IRF7. Recent findings indicate an involvement of K63-linked polyubiquitination and of the Golgi-localized protein Optineurin (OPTN) in the activation of this crucial kinase involved in innate anti-viral immunity. This review summarizes the sensing of viruses and the signaling leading to type I IFN production following TBK1 activation through its ubiquitination and the sensing of ubiquitin chains by OPTN at the Golgi apparatus.

Keywords: TBK1, Optineurin, Golgi apparatus., Viruses, innate immunity

Received: 30 Jan 2018; Accepted: 06 Apr 2018.

Edited by:

Ivana Munitic, University of Rijeka, Croatia

Reviewed by:

Jason Cannon, Purdue University, United States
Hiroyuki Oshiumi, Hokkaido University, Japan  

Copyright: © 2018 Outlioua, Pourcelot and Arnoult. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Damien Arnoult, INSERM UMR1197 Unité mixte de recherche Interactions cellules souches-niches, Villejuif, France,