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Front. Immunol. | doi: 10.3389/fimmu.2018.01434

Implication of GPR43 in intestinal inflammation: a mini-review

  • 1South China Agricultural University, China

Short chain fatty acids (SCFAs, e.g., acetate, propionate and butyrate) are a subset of fatty acids that are produced by gut microbiota during the fermentation of dietary fiber. Most beneficial roles of SCFAs in the gastrointestinal tract are mediated by directly activating its receptor, G-protein-coupled receptor 43 (GPR43, also known as FFAR2). Various recent studies have demonstrated the role of GPR43 in intestinal inflammatory diseases, such as inflammatory bowel diseases. Therefore, GPR43 could potentially be a drug target for intestinal inflammatory diseases. In this review, we review the current knowledge on the regulatory mechanisms associated with GPR43 in intestinal inflammation.

Keywords: GPR43, Inflammation, Short Chain Fatty Acids, Inflammatory Bowel Diseases, intestinal microbiota

Received: 15 Apr 2018; Accepted: 11 Jun 2018.

Edited by:

Pinyi Lu, DoD, Biotechnology HPC Software Applications Institute (BHSAI), United States

Reviewed by:

Chang Chen, University of Illinois at Chicago, United States
Zhanju Liu, Shanghai Tenth People's Hospital, Tongji University, China  

Copyright: © 2018 Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Wenkai Ren, South China Agricultural University, Guangzhou, China, renwenkai19@126.com