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Front. Immunol. | doi: 10.3389/fimmu.2019.01168

Lymphatic migration of immune cells

  • 1Institute for Systems Biology (ISB), United States
  • 2Garvan Institute of Medical Research, Australia

Lymphatic vessels collect interstitial fluid that has extravasated from blood vessels and return it to the circulatory system. Another important function of the lymphatic network is to facilitate immune cell migration and antigen transport from the periphery to draining lymph nodes. This migration plays a crucial role in immune surveillance, initiation of immune responses and tolerance. Here we discuss the significance and mechanisms of lymphatic migration of innate and adaptive immune cells in homeostasis, inflammation and cancer.

Keywords: immune, Migration, Lymphatic, innate immune cells, T cell

Received: 31 Jan 2019; Accepted: 08 May 2019.

Edited by:

Amanda W. Lund, Oregon Health & Science University, United States

Reviewed by:

Alanna Ruddell, University of Washington, United States
Maria M. Steele, Oregon Health & Science University, United States  

Copyright: © 2019 Hampton and Chtanova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Tatyana Chtanova, Garvan Institute of Medical Research, Darlinghurst, Australia, tatyana.chtanova@gmail.com