%A Shan,Juan %A Jin,Hong %A Xu,Yan %D 2020 %J Frontiers in Immunology %C %F %G English %K cell metabolism,T helper 17 cells,regulatory T cells,systemic lupus erythematosus,mTOR %Q %R 10.3389/fimmu.2020.01027 %W %L %M %P %7 %8 2020-May-22 %9 Mini Review %# %! Targeting T cell metabolism in SLE %* %< %T T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus %U https://www.frontiersin.org/articles/10.3389/fimmu.2020.01027 %V 11 %0 JOURNAL ARTICLE %@ 1664-3224 %X The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can regulate T cell differentiation and function, thus contributing to SLE inflammation. Increasingly, data have shown metabolism influences and reprograms the Th17/Treg cell balance, and the metabolic pattern of T cells is different in SLE. Notably, metabolic characteristics of SLE T cells, such as enhanced glycolysis, lipid synthesis, glutaminolysis, and highly activated mTOR, all favored Th17 differentiation and function, which underlie the Th17/Treg cell imbalance in SLE patients. Targeting metabolic pathways to reverse Th17/Treg imbalance offer a promising method for SLE therapy.