@ARTICLE{10.3389/fimmu.2021.626793, AUTHOR={Arnaout, Ramy A. and Prak, Eline T. Luning and Schwab, Nicholas and Rubelt, Florian and , the Adaptive Immune Receptor Repertoire Community and Arnaout, Ramy A. and Arora, Rohit and Bashford-Rogers, Rachael and Breden, Felix and Bukhari, Syed Ahmad Chan and Corrie, Brian and Cowell, Lindsay G. and Efroni, Sol and Gooley, Christopher and Greiff, Victor and Heiden, Jason Vander and Koguchi, Yoshinobu and Langerak, Ton and Lim, Theam Soon and Prak, Eline Luning and Mariotti-Ferrandiz, Encarnita and Marquez, Susanna and Meysman, Pieter and Miho, Enkelejda and Motwani, Keshav and Nouri, Nima and Pavlović, Milena and Rubelt, Florian and Sandve, Geir Kjetil and Schwab, Nicholas and Snapkov, Igor and Soto, Cinque and Stervbo, Ulrik and Trück, Johannes and van den Ham, Henk-Jan and Watson, Corey and Weber, Cédric R.}, TITLE={The Future of Blood Testing Is the Immunome}, JOURNAL={Frontiers in Immunology}, VOLUME={12}, YEAR={2021}, URL={https://www.frontiersin.org/articles/10.3389/fimmu.2021.626793}, DOI={10.3389/fimmu.2021.626793}, ISSN={1664-3224}, ABSTRACT={It is increasingly clear that an extraordinarily diverse range of clinically important conditions—including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers—leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person’s B cells (antibodies) and T cells. We refer to these as the immunome. Because of its diversity and complexity, the immunome provides singular opportunities for advancing personalized medicine by serving as the substrate for a highly multiplexed, near-universal blood test. Here we discuss some of these opportunities, the current state of immunome-based diagnostics, and highlight some of the challenges involved. We conclude with a call to clinicians, researchers, and others to join efforts with the Adaptive Immune Receptor Repertoire Community (AIRR-C) to realize the diagnostic potential of the immunome.} }