%A Ryan,Grace E. %A Harris,John E. %A Richmond,Jillian M. %D 2021 %J Frontiers in Immunology %C %F %G English %K Resident memory (T ) RM,cutaneous lupus erythematosus (CLE),Vitiligo,Psoriasis,Frontal fibrosing alopecia,Alopecia Aerata (AA),Cicatricial alopecia,Dermatology,autoimmunty %Q %R 10.3389/fimmu.2021.652191 %W %L %M %P %7 %8 2021-May-03 %9 Mini Review %+ Grace E. Ryan,Department of Dermatology, University of Massachusetts Medical School,United States,grace.ryan@umassmed.edu %+ Jillian M. Richmond,Department of Dermatology, University of Massachusetts Medical School,United States,grace.ryan@umassmed.edu %# %! TRM in Skin Autoimmunity %* %< %T Resident Memory T Cells in Autoimmune Skin Diseases %U https://www.frontiersin.org/articles/10.3389/fimmu.2021.652191 %V 12 %0 JOURNAL ARTICLE %@ 1664-3224 %X Tissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that TRM cells also form during autoimmunity. TRM mediated autoimmune diseases are particularly destructive, because unlike foreign antigens, the self-antigens are never cleared, continuously activating self-reactive TRM T cells. In this article, we will focus on how TRMs mediate disease in autoimmune skin conditions, specifically vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata and frontal fibrosing alopecia.